- Accumulated Amyloid-beta Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease被引量：205收藏
- 作者：Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing United Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2009
- 关键词：alpha 7nAChR amyloid-beta peptide (A beta) oxidative stress PI3K/Akt tau protein
- 质疑
- Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease被引量：89收藏
- 作者：Hong, Liang Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2014
- 关键词：Alzheimer's disease Amyloid-beta Degradation Proteasome Ubiquitin
- 质疑
- Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3 beta signaling pathway被引量：61收藏
- 作者：Huang, Han-Chang Tang, Di Xu, Ke Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ;Capital Normal Univ
- 来源：JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 2014
- 关键词：Amyloid-beta Alzheimer's disease curcumin GSK-3 beta PTEN tau hyperphosphorylation
- 质疑
- Curcumin-Mediated Neuroprotection Against Amyloid-beta-Induced Mitochondrial Dysfunction Involves the Inhibition of GSK-3 beta被引量：60收藏
- 作者：Huang, Han-Chang Xu, Ke Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Capital Normal Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2012
- 关键词：Alzheimer's disease amyloid-beta curcumin glycogen synthase kinase-3 beta mitochondrial dysfunction reactive oxygen species
- 质疑
- Cu(II) interaction with amyloid-beta peptide: A review of neuroactive mechanisms in AD brains被引量：49收藏
- 作者：Lin, Chang-Jun Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：BRAIN RESEARCH BULLETIN 2010
- 关键词：Alzheimer's disease (AD) Copper Amyloid precursor protein (APP) Amyloid-beta peptide (A beta) Reactive oxygen species (ROS) Signal pathway
- 质疑
- Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)被引量：41收藏
- 作者：Huang, Han-Chang Lin, Chang-Jun Liu, Wen-Juan Jiang, Rui-Rui Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：FOOD AND CHEMICAL TOXICOLOGY 2011
- 关键词：Alzheimer's disease (AD) Anti-oxidation Copper Curcumin Oxidative stress Pro-oxidation
- 质疑
- Protective Effects of Curcumin on Amyloid-beta-Induced Neuronal Oxidative Damage被引量：39收藏
- 作者：Huang, Han-Chang Chang, Ping Dai, Xue-Ling Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：NEUROCHEMICAL RESEARCH 2012
- 关键词：Alzheimer's disease (AD) Amyloid-beta (A beta) Curcumin Molecular interaction Oxidative damage
- 质疑
- Antioxidative and Neuroprotective Effects of Curcumin in an Alzheimer's Disease Rat Model Co-Treated with Intracerebroventricular Streptozotocin and Subcutaneous D-Galactose被引量：37收藏
- 作者：Huang, Han-Chang Zheng, Bo-Wen Guo, Yu Zhao, Jian Zhao, Jiang-Yan Ma, Xiao-Wei Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2016
- 关键词：Alzheimer's disease animal model curcumin D-galactose neurodegeneration streptozotocin
- 质疑
- Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species被引量：29收藏
- 作者：Xu, Wei Huang, Han-chang Lin, Chang-jun Jiang, Zhao-Feng
- 机构：Beijing Union Univ; Beijing Union Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2010
- 关键词：Copper Neurotoxicity COSs Neuroprotective effects Oxidative damage Cortical neurons
- 质疑
- Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease被引量：27收藏
- 作者：Huang, Han-Chang Tang, Di Lu, Shu-Yan Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2015
- 关键词：Alzheimer's disease Endoplasmic reticulum stress Unfolded protein response Amyloid-beta peptide Calcium Inflammation
- 质疑
- Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's disease被引量：26收藏
- 作者：Gu, Xue-Mei Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Mil Gen Hosp;Beijing Univ Chem Technol
- 来源：NEUROSCIENCE BULLETIN 2012
- 关键词：Alzheimer's disease amyloid-beta metabolic deficiency mitochondrial dysfunction
- 质疑
- Chitooligosaccharides Attenuate Cu2+-Induced Cellular Oxidative Damage and Cell Apoptosis Involving Nrf2 Activation被引量：25收藏
- 作者：Huang, Han-Chang Hong, Liang Chang, Ping Zhang, Jiao Lu, Shu-Yan Zheng, Bo-Wen Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2015
- 关键词：Alzheimer's disease Chitooligosaccharides Cu2+ Nrf2 Oxidative damage
- 质疑
- Protection of curcumin against amyloid- b- induced cell damage and death involves the prevention from NMDA receptor- mediated intracellular Ca2+ elevation被引量：23收藏
- 作者：Huang, Han-Chang Chang, Ping Lu, Shu-Yan Zheng, Bo-Wen Jiang, Zhao-Feng
- 机构：Beijing Union Univ
- 来源：JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 2015
- 关键词：Alzheimer's disease amyloid-beta calcium curcumin neuroprotection NMDA receptor
- 质疑
- Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease被引量：16收藏
- 作者：Zheng, Bo-Wen Yang, Li Dai, Xue-Ling Jiang, Zhao-Feng Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2016
- 关键词：Alzheimer disease APP processing Hippocampal synapses O-GlcNAcylation Tau phosphorylation
- 质疑
- 微生物法测定婴幼儿配方食品中生物素的不确定度评估被引量：14收藏
- 作者：商迎辉 章丽娜 李梦洁 赵范范 刘馨君 魏俊 黄汉昌 劳凤学
- 机构：北京市生物活性物质与功能食品研究院北京联合大学功能因子与脑科学研究院生物化学工程学院
- 来源：《中国食品学报》 2019
- 关键词：微生物法 婴幼儿配方食品 生物素 不确定度
- 摘要：按照食品安全国家标准GB 5009.259-2016规定的微生物法对婴幼儿配方食品中生物素含量进行测定,根据CNAS-CL07:2011要求并依据JJF1059.1-2012和GB/Z22553-2010对测定过程影响检...
- 质疑
- β-淀粉样蛋白的体内清除机制被引量：13收藏
- 作者：洪亮 黄汉昌 姜招峰 刘媛媛
- 机构：北京联合大学功能食品科学技术研究院;北京联合大学应用文理学院
- 来源：《生命科学研究》 2013
- 关键词：阿尔茨海默病 β-淀粉样蛋白 清除 降解 吞噬
- 摘要：阿尔茨海默病(alzheimer disease,AD)是一种神经退行性疾病,β-淀粉样蛋白(amyloid-β,Aβ)被认为是其发病的中心分子.体内Aβ产生和清除的平衡在阿尔茨海默病的病理过程中扮演了重要的角色.人体清...
- 质疑
- Modulation of A beta PP and GSK3 beta by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease被引量：11收藏
- 作者：Liu, Xin-jun Wei, Jun Shang, Ying-hui Huang, Han-chang Lao, Feng-xue
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2017
- 关键词：Alzheimer's disease amyloid-beta apoptosis endoplasmic reticulum stress neurofibrillary tangles
- 质疑
- Sleep-Wake Disorders in Alzheimer's Disease: A Review被引量：11收藏
- 作者：Sun, Yu-Ying Wang, Zhun Zhou, He-Yan Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2022
- 关键词：Alzheimer's disease (AD) sleep-wake disorders beta-amyloid (A beta) circadian rhythms neurotransmitters
- 质疑
- Regulation of A beta PP Glycosylation Modification and Roles of Glycosylation on A beta PP Cleavage in Alzheimer's Disease被引量：11收藏
- 作者：Tao, Peng-Fei Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease amyloid-beta precursor protein protein glycosylation O-linked N-acetyl-beta-D-glucosamine transferase O-GlcNAcase
- 质疑
- Amyloid-beta Protein Precursor family Members: A Review from Homology to Biological Function被引量：10收藏
- 作者：Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ;Beijing Univ Chem Technol
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2011
- 关键词：Alzheimer's disease amyloid-beta protein precursor biological function homology structure
- 质疑
- Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2被引量：8收藏
- 作者：Zhou, He-Yan Sun, Yu-Ying Chang, Ping Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2022
- 关键词：Curcumin Endoplasmic reticulum stress (ERS) Mitofusin-2 (Mfn2) Mitochondrial dysfunction SH-SY5Y cells Thapsigargin
- 质疑
- Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation被引量：8收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Ya-Xuan Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：MOLECULAR BIOLOGY REPORTS 2020
- 关键词：Alzheimer's disease Amyloid-beta protein precursor (APP) Amyloid-beta peptide Cell damage Hydrogen peroxide (H2O2) Curcumin Mitochondrial stress
- 质疑
- 骨髓间充质干细胞向神经细胞的分化被引量：8收藏
- 作者：安秀峰 黄汉昌 姜招峰
- 机构：北京联合大学功能食品科学技术研究院
- 来源：《生命科学》 2013
- 关键词：骨髓间充质干细胞 神经细胞 影响因素
- 摘要：近年来,骨髓间充质干细胞逐渐成为神经科学领域的研究热点,广泛用于治疗神经退行性疾病,其原因是;骨髓间充质干细胞可在诱导物存在下定向分化为有功能的神经元细胞,并能成功表达神经标志蛋白。结合近几年的研究进展,主要从骨髓间充质...
- 质疑
- Phosphorylation and Glycosylation of Amyloid-beta Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer's Disease被引量：7收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Yu-Ying Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2021
- 关键词：Alzheimer's disease amyloid-beta protein precursor protein glycosylation protein phosphorylation
- 质疑
- 姜黄素对D-半乳糖致衰老大鼠氧化应激及Nrf2/ARE通路的影响被引量：7收藏
- 作者：郭豫 赵建 赵江燕 姜招峰 张冬雪 黄汉昌
- 机构：北京联合大学功能食品科学技术研究院;北京联合大学应用文理学院
- 来源：《华西药学杂志》 2016
- 关键词：姜黄素 D-半乳糖 氧化应激 Nrf2 抗氧化应激元件 衰老 抗氧化 蛋白表达
- 摘要：目的研究姜黄素对D-半乳糖致衰老模型大鼠氧化应激及Nrf2/ARE通路的影响。方法将大鼠随机均分为空白组、模型组和姜黄素组于模型组和姜黄素组大鼠每日sc 125 mg·kg-1D-半乳糖造模,姜黄素组大鼠同时ip 10 ...
- 质疑
- 聚乳酸高分子材料的生物安全性评价被引量：5收藏
- 作者：徐峰 郭豫 赵江燕 赵健 黄汉昌 姜招峰
- 机构：北京联合大学功能食品科学技术研究院
- 来源：《中国包装工业》 2014
- 关键词：生物降解塑料 聚乳酸高分子材料 生物安全评价
- 摘要：对可降解聚乳酸塑料进行生物学安全性评价,为食品包装材料的应用提供依据。参照原中华人民共和国卫生部《化学品毒性鉴定技术规范》中生物学评价的方法和要求,对聚乳酸塑料急性毒性、亚急性毒性试验,致突变毒性(Ames试验、小鼠淋巴...
- 质疑
- 实验室质量管理体系在食品理化检测实验教学中的应用被引量：4收藏
- 作者：秦菲 黄汉昌 刘彦霞 刘洋
- 机构：北京联合大学生物化学工程学院食品科学系
- 来源：《教育教学论坛》 2019
- 关键词：食品理化检测实验 实验室质量管理体系 ISO/IEC17025
- 摘要：食品理化检测实验是食品质量与安全专业的核心实验课程,为了提高学生实践能力,培养与实际岗位要求零距离人才,在食品理化检测实验室初步建立实验室质量管理体系,将ISO/IEC17025管理理念应用于食品理化检测实验教学过程中,...
- 质疑
- 基于创新能力培养的分子生物学实验教学的改革与实践被引量：4收藏
- 作者：高丽萍 高兆兰 黄汉昌 戴雪伶
- 机构：北京联合大学生物化学与工程学院食品科学系
- 来源：《教育教学论坛》 2020
- 关键词：实验课程 分子生物学 教学改革
- 摘要：文章针对硕士研究生分子生物学课程的特点,从优化教学内容、改革教学方法和手段等方面进行教学改革,使该课程真正满足知识经济时代培养研究创新型人才的需求。
- 质疑
- 诱导多能干细胞在治疗阿尔茨海默病中的应用进展被引量：4收藏
- 作者：李梦洁 章丽娜 商迎辉 黄汉昌 劳凤学
- 机构：生物活性物质与功能食品北京市重点实验室/北京联合大学功能因子与脑科学研究院/生物化学工程学院
- 来源：《解放军医学杂志》 2021
- 关键词：阿尔茨海默病 诱导多能干细胞 细胞模型 细胞移植 药物筛选
- 摘要：阿尔茨海默病(AD)是常见的慢性神经退行性疾病之一,主要表现为β淀粉样蛋白(Aβ)沉积、tau蛋白过度磷酸化及神经元和突触丢失等。目前已被批准的药物只能减缓症状,无法完全治愈本病。干细胞具有特殊的自我更新、增殖、分化和重...
- 质疑
- 姜黄素对Aβ_(1-42)诱导的细胞损伤和线粒体途径细胞凋亡的抑制作用被引量：3收藏
- 作者：路书彦 杨丽 戴雪伶 常平 姜招峰 黄汉昌
- 机构：北京联合大学功能食品科学技术研究院;北京联合大学生物活性物质与功能食品北京市重点实验室
- 来源：《中国药理学与毒理学杂志》 2017
- 关键词：阿尔茨海默病 姜黄素 β-淀粉样蛋白 线粒体膜电位 细胞凋亡
- 摘要：目的探讨姜黄素对Aβ_(1-42)诱导的细胞损伤和凋亡的抑制作用。方法采用体外培养的人神经母细胞瘤SH-SY5Y细胞,分为溶剂对照组、Aβ_(1-42)10μmol·L^(-1)损伤组、Aβ_(1-42)10μmol·L...
- 质疑
