文献类型：期刊文献

英文题名：Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease

作者：Zheng, Bo-Wen[1];Yang, Li[1];Dai, Xue-Ling[1,2];Jiang, Zhao-Feng[1,2];Huang, Han-Chang[1,2]

第一作者：Zheng, Bo-Wen

通讯作者：Huang, HC[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Appl Sci & Humanities, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2016

卷号：38

期号：2

起止页码：177-186

外文期刊名：NEUROLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-84978434500);WOS:【SCI-EXPANDED(收录号:WOS:000375152400013)】；

基金：This study was supported by the National Natural Science Foundation of China (31471587) and the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions (CIT&TCD201504034).

语种：英文

外文关键词：Alzheimer disease; APP processing; Hippocampal synapses; O-GlcNAcylation; Tau phosphorylation

摘要：Alzheimer disease (AD), a central nervous system degenerative disease, is characterized by abnormal deposition of amyloid-beta peptide (A beta), neurofibrillary tangles formed by hyperphosphorylated tau and synaptic loss. It is widely accepted that A beta is the chief culprit of AD. A beta peptide is the cleavage product of amyloid-beta precursor protein (APP). Recently, more attention has been paid to O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) modification of protein. O-GlcNAcylation plays a significant role in hippocampal synaptic function. Abated O-GlcNAcylation might be a modulator in progression of AD through regulating activity of pertinent enzymes and factors. Evidence suggests that enhanced O-GlcNAcylation interacts with tau phosphorylation and prevents brain from tau and A beta-induced impairment. Here, we review the roles of O-GlcNAcylation in APP cleavage, tau phosphorylation and hippocampal synapses function.