文献类型：期刊文献

英文题名：Phosphorylation and Glycosylation of Amyloid-beta Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer's Disease

作者：Song, Xi-Jun[1,2];Zhou, He-Yan[1,2];Sun, Yu-Ying[1,2];Huang, Han-Chang[1,2]

第一作者：Song, Xi-Jun

通讯作者：Huang, HC[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Res Inst Funct Factors & Brain Sci, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2021

卷号：84

期号：3

起止页码：937-957

外文期刊名：JOURNAL OF ALZHEIMERS DISEASE

收录：;Scopus(收录号：2-s2.0-85120477786);WOS:【SCI-EXPANDED(收录号:WOS:000722640800002)】；

基金：This study was supported by the Academic Research Projects of Beijing Union University (JZ10202001, XP202008, and ZK70202101).

语种：英文

外文关键词：Alzheimer's disease; amyloid-beta protein precursor; protein glycosylation; protein phosphorylation

摘要：Alzheimer's disease (AD) is a neurodegenerative disorder in the central nervous system, and this disease is characterized by extracellular senile plaques and intracellular neurofibrillary tangles. Amyloid-beta (A beta) peptide is the main constituent of senile plaques, and this peptide is derived from the amyloid-beta protein precursor (A beta PP) through the successive cleaving by beta-site A beta PP-cleavage enzyme 1 (BACE1) and beta-secretase. A beta PP undergoes the progress of post-translational modifications, such as phosphorylation and glycosylation, which might affect the trafficking and the cleavage of A beta PP. In the recent years, about 10 phosphorylation sites of A beta PP were identified, and they play complex roles in glycosylation modification and cleavage of A beta PP. In this article, we introduced the transport and the cleavage pathways of A beta PP, then summarized the phosphorylation and glycosylation sites of A beta PP, and further discussed the links and relationship between phosphorylation and glycosylation on the pathways of A beta PP trafficking and cleavage in order to provide theoretical basis for AD research.