文献类型：期刊文献

英文题名：Modulation of A beta PP and GSK3 beta by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease

作者：Liu, Xin-jun[1,2];Wei, Jun[1,2];Shang, Ying-hui[1,2];Huang, Han-chang[1,2];Lao, Feng-xue[1,2]

通讯作者：Lao, FX[1];Lao, FX[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2017

卷号：57

期号：4

起止页码：1157-1170

外文期刊名：JOURNAL OF ALZHEIMERS DISEASE

收录：;Scopus(收录号：2-s2.0-85018737617);WOS:【SCI-EXPANDED(收录号:WOS:000399933800013)】；

语种：英文

外文关键词：Alzheimer's disease; amyloid-beta; apoptosis; endoplasmic reticulum stress; neurofibrillary tangles

摘要：Alzheimer's disease (AD) is a dementia disease with neuronal loss and synaptic impairment. This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-beta (A beta) peptides. The amyloid-beta protein precursor (A beta PP) and glycogen synthase kinase-3 beta (GSK3 beta) are two main proteins associated with AD and are closely correlated with these hallmarks. Recently, both of the proteins were reported to be modulated by endoplasmic reticulum stress (ERS) and are involved in the pathogenesis of AD. The mechanism of ERS plus the modulation of A beta PP processing and GSK3 beta activity by ERS in AD are summarized and explored in this review.