文献类型：期刊文献

英文题名：Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease

作者：Lin, M.[1,2];Yu, J. -X[1,2];Zhang, W. -X[1,2];Lao, F. -X[1];Huang, H-C[1,2]

通讯作者：Huang, HC[1];Huang, HC[2];Huang, HC[3]|[114178fa0f3495b988733]黄汉昌;

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[2]Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing 100023, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[2]corresponding author), Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing 100023, Peoples R China;[3]corresponding author), 18 Fatou Third Block, Beijing, Peoples R China.|[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;[114172]北京联合大学应用文理学院;

年份：2024

外文期刊名：JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE

收录：;Scopus(收录号：2-s2.0-85203344224);WOS:【SCI-EXPANDED(收录号:WOS:001308268600001)】；

基金：This study was supported by the Academic Research Projects of Beijing Union University (ZKZD202304 and ZK70202101).

语种：英文

外文关键词：Alzheimer's disease (AD); triggering receptor expressed on myeloid cells 2 (TREM2); microglia; A beta; monoclonal antibody

摘要：Alzheimer's disease (AD) is an age-related degenerative disease, which is characteristic by the deposition of senile plaques (SP) outside the cells, the neurofibrillary tangles (NFTs) inside the neurons, and the loss of synapse and neurons. Neuroinflammation may play an important role in the pathogenesis of AD. Microglia are the immune cells in the central nervous system. However, microglia might become disease-related microglia (DAMs) when stimulated by the external environment. DAMs have been shown to be involved in a series of events of AD development including A beta accumulation and tau phosphorylation. The triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor that is mainly expressed by microglia in the central nervous system (CNS). TREM2 plays an important role in the physiological function of microglia, and the dyshomeostasis of TREM2 is related to the development of late-onset AD. This article summarized the latest advances in TREM2 biology and its impact on the roles of microglia in AD development, with a particular emphasis on the structure, ligands, signal transduction, and the agonistic antibodies of TREM2 for AD treatment. We further discussed the survival, migration, phagocytosis, inflammation, and cellular metabolism of microglia, as well as the role of sTREM2 in neuroprotection and as a biomarker for AD. It provides a reference for further research on the molecular mechanism of microglial TREM2 in the occurrence and development of AD and on the therapeutic strategies targeted on the microglial TREM2.