文献类型：期刊文献

英文题名：Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease

作者：Huang, Han-Chang[1,2];Tang, Di[1,2];Lu, Shu-Yan[1,2];Jiang, Zhao-Feng[1,2]

第一作者：黄汉昌

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2015

卷号：37

期号：4

起止页码：366-374

外文期刊名：NEUROLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-84921762084);WOS:【SCI-EXPANDED(收录号:WOS:000347918400013)】；

基金：This research was supported by National Natural Science Foundation of China (Grant No. 31071512) and the Scientific Research Common Program of Beijing Municipal Commission of Education (SQKM201411417003).

语种：英文

外文关键词：Alzheimer's disease; Endoplasmic reticulum stress; Unfolded protein response; Amyloid-beta peptide; Calcium; Inflammation

摘要：Alzheimer's disease (AD) is one of the most common types of progressive dementias. The typical neuropathological changes in AD include extracellular senile plaques, intracellular neurofibrillary tangles, and loss of neurons. The pathogenetic mechanism of this disease is not comprehensively understood yet. Recently, endoplasmic reticulum stress (ER stress) has been considered as a potential event involved in AD development. Some AD-related factors, such as misfolded protein and Ca2+ depletion, could disrupt the homeostasis of ER lumen. In AD, the aggregated amyloid-beta peptide (Abeta) could induce ER stress in an assembly dependent way. The presenilin has been identified as a Ca2+ channel. Mutations of presenilin could change the balance of Ca2+ in ER lumen and thus disrupts the ER homeostasis. Furthermore, the ER stress could lead to cellular disorders like inflammation. Through activating the expression of inflammatory factors, ER stress triggers inflammatory response in AD pathology. Herein, we reviewed the recent progress of ER stress-induced unfolded protein response (UPR) and the roles of ER stress in AD pathological process.