文献类型：期刊文献

英文题名：Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)

作者：Huang, Han-Chang[1,2,3];Lin, Chang-Jun[1,3];Liu, Wen-Juan[1,3];Jiang, Rui-Rui[1,3];Jiang, Zhao-Feng[1,3]

第一作者：黄汉昌;Huang, Han-Chang

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China;[3]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2011

卷号：49

期号：7

起止页码：1578-1583

外文期刊名：FOOD AND CHEMICAL TOXICOLOGY

收录：;Scopus(收录号：2-s2.0-79957643523);WOS:【SCI-EXPANDED(收录号:WOS:000292352800013)】；

基金：This research was supported by Scientific Research Common Program of Beijing Municipal Commission of Education (KM201011417002) and by Project 31071512 supported by National Natural Science Foundation of China.

语种：英文

外文关键词：Alzheimer's disease (AD); Anti-oxidation; Copper; Curcumin; Oxidative stress; Pro-oxidation

摘要：Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Elevated copper (Cu) ions are thought to link AD pathology. Curcumin is suggested to treat AD because of its high anti-oxidative activity and coordination to transitional metal ions. In this study, the protective effect of curcumin against the Cu(II)-induced oxidative damage was investigated in primary rat cortical neurons. The neuronal damage was assessed by morphological observation, cell viability, and oxidative stress level. The results showed that curcumin at low dosage protected primary cultured neurons from the 20 mu M Cu(II)-induced damage. Low dosage of curcumin depressed oxidative stress levels exacerbated by Cu(II). However, high dosage of curcumin failed to decrease the Cu(II)-induced oxidative stress. When Cu(II) was presented in primary neurons, curcumin at high dosage resulted in chromosomal aberration and cell damage. These results suggest that curcumin, in a concentration-dependent manner, plays both anti-oxidative and pro-oxidative roles in primary neurons treated with Cu(II). (C) 2011 Elsevier Ltd. All rights reserved.