文献类型：期刊文献

英文题名：Regulation of A beta PP Glycosylation Modification and Roles of Glycosylation on A beta PP Cleavage in Alzheimer's Disease

作者：Tao, Peng-Fei[1];Huang, Han-Chang[1]

第一作者：Tao, Peng-Fei

通讯作者：Huang, HC[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2019

卷号：10

期号：5

起止页码：2115-2124

外文期刊名：ACS CHEMICAL NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-85065880978);WOS:【SCI-EXPANDED(收录号:WOS:000468369500006)】；

基金：This study was supported by the National Natural Science Foundation of China (Grant No. 31471587), Premium Funding Project for Academic Human Resources Development in Beijing Union University (Grant No. BPHR2018CZ02), and the Scientific Research Project from Facing Characteristic Discipline of Beijing Union University (Grant No. KYDE40201703).

语种：英文

外文关键词：Alzheimer's disease; amyloid-beta precursor protein; protein glycosylation; O-linked N-acetyl-beta-D-glucosamine transferase; O-GlcNAcase

摘要：The presence of senile plaques in the gray matter of the brain is one of the major pathologic features of Alzheimer's disease (AD), and amyloid-beta (A beta) is the main component of extracellular deposits of the senile plaques. derives from amyloid-beta precursor protein (A beta PP) cleaved by beta-secretase (BACE1) and gamma-secretase, and the abnormal cleavage of A beta PP is an important event leading to overproduction and aggregation of A beta species. After translation, A beta PP undergoes post-translational modifications (PTMs) including glycosylation and phosphorylation in the endoplasmic reticulum (ER) and Golgi apparatus, and these modifications play an important role in regulating the cleavage of this protein. In this Review, we summarize research progress on the modification of glycosylation, especially O-GlcNAcylation and mucin-type O-linked glycosylation (also known as O-GalNAcylation), on the regulation of A beta PP cleavage and on the influence of A beta PP's glycosylation in the pathogenesis of AD.