文献类型：期刊文献

英文题名：Sleep-Wake Disorders in Alzheimer's Disease: A Review

作者：Sun, Yu-Ying[1,2];Wang, Zhun[1,2];Zhou, He-Yan[1,2];Huang, Han-Chang[1,2]

第一作者：Sun, Yu-Ying

通讯作者：Huang, HC[1];Huang, HC[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Res Inst Funct Factors & Brain Sci, Beijing 100023, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Beijing Union Univ, Res Inst Funct Factors & Brain Sci, Beijing 100023, Peoples R China.|[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;[114172]北京联合大学应用文理学院;

年份：2022

卷号：13

期号：10

起止页码：1467-1478

外文期刊名：ACS CHEMICAL NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-85130036724);WOS:【SCI-EXPANDED(收录号:WOS:000818312900001)】；

基金：This study was supported by the Academic Research Projects of Beijing Union University (Grants JZ10202001, XP202008, and ZK70202101).

语种：英文

外文关键词：Alzheimer's disease (AD); sleep-wake disorders; beta-amyloid (A beta); circadian rhythms; neurotransmitters

摘要：Alzheimer's disease (AD) is a multifactorial disease, and it has become a serious health problem in the world. Senile plaques (SPs) and neurofibrillary tangles (NFTs) are two main pathological characters of AD. SP mainly consists of aggregated beta-amyloid (A beta), and NFT is formed by hyperphosphorylated tau protein. Sleep-wake disorders are prevalent in AD patients; however, the links and mechanisms of sleep-wake disorders on the AD pathogenesis remain to be investigated. Here, we referred to the sleep-wake disorders and reviewed some evidence to demonstrate the relationship between sleep-wake disorders and the pathogenesis of AD. On one hand, the sleep-wake disorders may lead to the increase of A beta production and the decrease of A beta clearance, the spreading of tau pathology, as well as oxidative stress and inflammation. On the other hand, the ApoE4 allele, a risk gene for AD, was reported to participate in sleep-wake disorders. Furthermore, some neurotransmitters, such as acetylcholine, glutamate, serotonin, melatonin, and orexins, and their receptors were suggested to be involved in AD development and sleep-wake disorders. We discussed and suggested some possible therapeutic strategies for AD treatment based on the view of sleep regulation. In general, this review explored different views to find novel targets of diagnosis and therapy for AD.