文献类型：期刊文献

英文题名：Biomedical imaging and visualization model of mitochondrial dysfunction and oxidative stress in alzheimer disease

作者：Lin, Chang-Jun[1]; Huang, Han-Chang[1]; Liu, Wen-Juan[1]; Jiang, Zhao-Feng[1]

第一作者：Lin, Chang-Jun

通讯作者：Lin, C.-J.

机构：[1] Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Arts and Science, Beijing Union University, Beijing 100191, China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

年份：2012

卷号：138-139

起止页码：1179-1182

外文期刊名：Applied Mechanics and Materials

收录：EI(收录号：20114814571686)

语种：英文

外文关键词：Mitochondria - Visualization - Neurodegenerative diseases - Cell membranes - Oxidative stress - Chromosomes - Cytology - Medical imaging

摘要：Mitochondrial dysfunction and oxidative stress are among the earliest events linked to Alzheimer Disease and might play a causative role in disease onset and progression. In this paper, a biomedical imaging and visualization model was set to investigate the mitochondrial dysfunction and oxidative stress in Aβ/Cu2+-treated cells, which contribute in a significant manner to bioenergetic failure and mitochondrial dysfunction, by measuring mitochondrial membrane potential, Ca2+, chromatin condensation and ROS. This evaluating method opens a window for analyzing the protective effect of a certain substance in improving mitochondrial function and preventing oxidative stress in AD development.