文献类型：期刊文献

英文题名：Cu(II) interaction with amyloid-beta peptide: A review of neuroactive mechanisms in AD brains

作者：Lin, Chang-Jun[1,2];Huang, Han-Chang[1,2];Jiang, Zhao-Feng[1,2]

第一作者：Lin, Chang-Jun

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Coll Arts & Sci, Beijing, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China

第一机构：北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Arts & Sci, Beijing, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;

年份：2010

卷号：82

期号：5-6

起止页码：235-242

外文期刊名：BRAIN RESEARCH BULLETIN

收录：;Scopus(收录号：2-s2.0-77955088624);WOS:【SCI-EXPANDED(收录号:WOS:000281329500001)】；

基金：This research was supported by Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality (PHR(IHLB)) [PHR20090514], and by Scientific Research Common Program of Beijing Municipal Commission of Education (KM201011417002).

语种：英文

外文关键词：Alzheimer's disease (AD); Copper; Amyloid precursor protein (APP); Amyloid-beta peptide (A beta); Reactive oxygen species (ROS); Signal pathway

摘要：Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the dyshomeostasis of biometal metabolism, the extracellular accumulation of neurotoxic amyloid-beta (A beta) peptide, the intracellular accumulation of hyperphosphorylated tau and the loss of synapses. Copper plays a key role in AD development. The A beta peptide and amyloid precursor protein (APP), the parental molecule of A beta, are modulated by copper in the brain. Increased copper concentration has been found in the AD brain that implies that copper may participate in the pathophysiology of AD. Copper can bind to APP and A beta, then affects the structure and toxic of APP and A beta. Some researchers have reported that copper could affect the formation of beta-sheet structure that is widely accepted as toxic secondary structure of A beta. This review explores the role of copper on the conformation and aggregation of A beta, and the copper-induced neuroactive mechanisms. Copper may be involved in the following pathways to affect the neuroactivation of A beta: (1) change of the secondary structure of A beta; (2) induction of oxidative stress in AD brains, and (3) regulation of cellular signal pathway. Thus, correcting brain copper imbalance may represent a relevant therapeutic target for Alzheimer's disease. (C) 2010 Elsevier Inc. All rights reserved.