文献类型：期刊文献

英文题名：Accumulated Amyloid-beta Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

作者：Huang, Han-Chang[1,2];Jiang, Zhao-Feng[1,2]

第一作者：黄汉昌

通讯作者：Jiang, ZF[1]

机构：[1]Beijing United Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100083, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing United Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100083, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2009

卷号：16

期号：1

起止页码：15-27

外文期刊名：JOURNAL OF ALZHEIMERS DISEASE

收录：;Scopus(收录号：2-s2.0-58849143335);WOS:【SCI-EXPANDED(收录号:WOS:000263262000002)】；

基金：Supported by the Open Project Program of Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University.

语种：英文

外文关键词：alpha 7nAChR; amyloid-beta peptide (A beta); oxidative stress; PI3K/Akt; tau protein

摘要：The neuropathology associated with Alzheimer's disease (AD) is characterized by the presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the loss of basal forebrain cholinergic neurons. The neuritic plaque is composed of a core of amyloid-beta peptide (A beta) while the neurofibrillary tangles contain phosphorylated tau protein, and, as such, both A beta and tau are important molecules associated with AD. In healthy human bodies, clearance mechanisms for A beta are available; yet if clearance fails, A beta accumulates, increasing the risk of neurotoxicity in the brain. Tau, one of the main microtubule-associated proteins, will be hyperphosphorylated and lose the ability to bind microtubules when the homeostasis of phosphorylation and dephosphorylation is disturbed in neurons. Accumulated A beta and hyperphosphorylated tau are thought to be coexistent. Research on the pathological changes in AD indicates that accumulated A beta in vivo may initiate the hyperphosphorylation of tau. Also, the signal transduction pathways of tau hyperphosphorylation may be related to accumulated A beta. In this review, we will discuss how A beta accumulates, how tau protein is hyperphosphorylated, and how accumulated A beta initiates hyperphosphorylation of tau protein in AD.