文献类型：期刊文献

英文题名：Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches

作者：Sun, Yu-Ying[1,2];Wang, Zhun[1,2];Huang, Han-Chang[1,2]

第一作者：Sun, Yu-Ying

通讯作者：Huang, HC[1];Huang, HC[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing 100023, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing 100023, Peoples R China.|[11417]北京联合大学;[114172]北京联合大学应用文理学院;[1141726]北京联合大学生物化学工程学院;

年份：2023

外文期刊名：CELLULAR AND MOLECULAR NEUROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85160320721);WOS:【SCI-EXPANDED(收录号:WOS:000994933000001)】；

基金：Funding was provide by Academic Research Projects of Beijing Union University (Grant Numbers JZ10202001, XP202008 and ZK70202101).

语种：英文

外文关键词：Apolipoprotein E4 (ApoE4); Alzheimer's disease (AD); beta-Amyloid (A beta); Therapy

摘要：The Apolipoprotein E epsilon 4 (ApoE epsilon 4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence indicated that ApoE4 contributes to AD through influencing beta-amyloid (A beta) deposition and clearance. However, the molecular mechanisms of ApoE4 involved in AD pathogenesis remains unclear. Here, we introduced the structure and functions of ApoE isoforms, and then we reviewed the potential mechanisms of ApoE4 in the AD pathogenesis, including the effect of ApoE4 on A beta pathology, and tau phosphorylation, oxidative stress; synaptic function, cholesterol transport, and mitochondrial dysfunction; sleep disturbances and cerebrovascular integrity in the AD brains. Furthermore, we discussed the available strategies for AD treatments that target to ApoE4. In general, this review overviews the potential roles of ApoE4 in the AD development and suggests some therapeutic approaches for AD. [GRAPHICS] .