文献类型：期刊文献

中文题名：骨髓间充质干细胞向神经细胞的分化

英文题名：Bone marrow mesenchymal stem cells differentiation into nerve cells

作者：安秀峰[1];黄汉昌[1];姜招峰[1]

第一作者：安秀峰

机构：[1]北京联合大学功能食品科学技术研究院,生物活性物质与功能食品北京市重点实验室,北京100191

第一机构：北京联合大学生物化学工程学院功能食品科学技术研究院|北京联合大学应用文理学院

年份：2013

卷号：25

期号：1

起止页码：84-90

中文期刊名：生命科学

外文期刊名：Chinese Bulletin of Life Sciences

收录：CSTPCD;;CSCD:【CSCD_E2013_2014】；

基金：国家自然科学基金面上项目(31071512);北京市属高等学校人才强教计划高层次人才资助项目(PHR20090514)

语种：中文

中文关键词：骨髓间充质干细胞;神经细胞;影响因素

外文关键词：bone marrow mesenchymal stem cells; nerve cells; factors

摘要：近年来,骨髓间充质干细胞逐渐成为神经科学领域的研究热点,广泛用于治疗神经退行性疾病,其原因是;骨髓间充质干细胞可在诱导物存在下定向分化为有功能的神经元细胞,并能成功表达神经标志蛋白。结合近几年的研究进展,主要从骨髓间充质干细胞的临床试验和应用;激光辐射、氧气含量和神经细胞对骨髓间充质干细胞分化为神经细胞的影响;microRNA、Notch信号通路和Wnt信号通路对骨髓间充质干细胞分化为神经细胞的调节作用等三方面进行阐述。
For the past few years, bone marrow mesenchymal stem cells ha,~e gradually become a research focus in the field of neuroscience, and have been widely used in the treatment of neurodegenerative diseases. It is just because that it can differentiate into functional neuron and express neural marker proteins successfully when inducer exists. Combined with the recent research progress, this paper will introduce the bone marrow mesenchymal stem cells from the following three aspects： firstly, the clinical trial and application of bone marrow mesenchymal stem cells; secondly, the＇ effects of laser radiation, oxygen content and the nerve cells on the process of bone marrow mesenchymal stem cells differentiate into nerve cells; thirdly, microRNA, Notch signal pathway and Wnt signal pathway regulate the process of bone marrow mesenchymal stem cells differentiating into nerve cells.