文献类型：期刊文献

英文题名：Protection of curcumin against amyloid- b- induced cell damage and death involves the prevention from NMDA receptor- mediated intracellular Ca2+ elevation

作者：Huang, Han-Chang[1];Chang, Ping[1];Lu, Shu-Yan[1];Zheng, Bo-Wen[1];Jiang, Zhao-Feng[1]

第一作者：黄汉昌

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Coll Arts & Sci, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Arts & Sci, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2015

卷号：35

期号：5

起止页码：450-457

外文期刊名：JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000367817300014)】；

基金：The authors report that they have no conflicts of interest. This study was supported by the National Natural Science Foundation of China (Grant no. 31471587) and the Scientific Research Common Program of Beijing Municipal Commission of Education (SQKM201411417003).

语种：英文

外文关键词：Alzheimer's disease; amyloid-beta; calcium; curcumin; neuroprotection; NMDA receptor

摘要：Alzheimer's disease (AD) is one of the common neurodegenerative diseases and amyloid- (A) is thought to be a key molecule contributing to AD pathology. Recently, curcumin is supposed to be beneficial to AD treatment. This study investigates the inhibitory effects of curcumin on A-induced cell damage and death involving NMDA receptor-mediated intracellular Ca2+ elevation in human neuroblastoma SH-SY5Y cells. Cells were impaired significantly in A-damaged group compared with the control group, and cell viability was decreased while the released LDH from the cytosol was increased. Curcumin promotes cell growth and decreases cell impairment induced by A. Curcmin attenuates A-induced elevation of the ratio of cellular glutamate/-aminobutyric acid (GABA) with a concentration-dependent manner. Curcumin inhibits A-induced increase of cellular Ca2+ and depresses A-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1). These results indicated that curcumin inhibits A-induced neuronal damage and cell death involving the prevention from intracellular Ca2+ elevation mediated by the NMDA receptor.