文献类型：期刊文献

英文题名：Amyloid-beta Protein Precursor Family Members: A Review from Homology to Biological Function

作者：Huang, Han-Chang[1,2,3];Jiang, Zhao-Feng[1,2]

第一作者：黄汉昌;Huang, Han-Chang

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China;[3]Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng W Rd, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2011

卷号：26

期号：4

起止页码：607-626

外文期刊名：JOURNAL OF ALZHEIMERS DISEASE

收录：;Scopus(收录号：2-s2.0-80055039585);WOS:【SCI-EXPANDED(收录号:WOS:000295843000002)】；

基金：This research was supported by Project 31071512 Supported by National Natural Science Foundation of China and by Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality (PHR(IHLB)) [PHR20090514].

语种：英文

外文关键词：Alzheimer's disease; amyloid-beta protein precursor; biological function; homology; structure

摘要：Alzheimer's disease (AD) is one of the most common forms of neurodegenerative disease. Amyloid-beta peptide (A beta) is the most crucial molecule related to the pathological development of AD. Amyloid-beta protein precursor (A beta PP) is one of A beta PP family members with conserved type I transmembrane. The genetic mutations of A beta PP and the abnormity of its post-transcription and proteolytic processing contribute to the elevation of A beta. The accumulation of A beta in senile plaques is believed to be the most important event in AD pathology. Therefore, as a key upstream molecule of A beta, A beta PP is related to the AD pathology, but the biological function of A beta PP is still not fully clear. A beta PP-like proteins are widely expressed in multicellular eukaryotes. A beta PP-like homologous genes and proteins are highly conserved in various organisms from invertebrates to mammals. A beta PP-like genes undergo similarly pathways of transcription and post-transcription processing, and A beta PP-like proteins is proteolyzed by the similar alpha-cleavage and the beta-cleavage pathways. Based on the homology and the resemble domains, A beta PP may play similar roles in organisms. In this article, we reviewed homology and structures of A beta PP family members in organisms and further discussed potential biological function in normal and AD brains.