成果/Result
- Accumulated Amyloid-beta Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease被引量：239收藏
- 作者：Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing United Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2009
- 关键词：alpha 7nAChR amyloid-beta peptide (A beta) oxidative stress PI3K/Akt tau protein
- Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease被引量：120收藏
- 作者：Hong, Liang Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2014
- 关键词：Alzheimer's disease Amyloid-beta Degradation Proteasome Ubiquitin
- Curcumin-Mediated Neuroprotection Against Amyloid-beta-Induced Mitochondrial Dysfunction Involves the Inhibition of GSK-3 beta被引量：81收藏
- 作者：Huang, Han-Chang Xu, Ke Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Capital Normal Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2012
- 关键词：Alzheimer's disease amyloid-beta curcumin glycogen synthase kinase-3 beta mitochondrial dysfunction reactive oxygen species
- Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3 beta signaling pathway被引量：73收藏
- 作者：Huang, Han-Chang Tang, Di Xu, Ke Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ;Capital Normal Univ
- 来源：JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 2014
- 关键词：Amyloid-beta Alzheimer's disease curcumin GSK-3 beta PTEN tau hyperphosphorylation
- Cu(II) interaction with amyloid-beta peptide: A review of neuroactive mechanisms in AD brains被引量：53收藏
- 作者：Lin, Chang-Jun Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：BRAIN RESEARCH BULLETIN 2010
- 关键词：Alzheimer's disease (AD) Copper Amyloid precursor protein (APP) Amyloid-beta peptide (A beta) Reactive oxygen species (ROS) Signal pathway
- Antioxidative and Neuroprotective Effects of Curcumin in an Alzheimer's Disease Rat Model Co-Treated with Intracerebroventricular Streptozotocin and Subcutaneous D-Galactose被引量：47收藏
- 作者：Huang, Han-Chang Zheng, Bo-Wen Guo, Yu Zhao, Jian Zhao, Jiang-Yan Ma, Xiao-Wei Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2016
- 关键词：Alzheimer's disease animal model curcumin D-galactose neurodegeneration streptozotocin
- Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)被引量：46收藏
- 作者：Huang, Han-Chang Lin, Chang-Jun Liu, Wen-Juan Jiang, Rui-Rui Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：FOOD AND CHEMICAL TOXICOLOGY 2011
- 关键词：Alzheimer's disease (AD) Anti-oxidation Copper Curcumin Oxidative stress Pro-oxidation
- Protective Effects of Curcumin on Amyloid-beta-Induced Neuronal Oxidative Damage被引量：42收藏
- 作者：Huang, Han-Chang Chang, Ping Dai, Xue-Ling Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：NEUROCHEMICAL RESEARCH 2012
- 关键词：Alzheimer's disease (AD) Amyloid-beta (A beta) Curcumin Molecular interaction Oxidative damage
- Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species被引量：35收藏
- 作者：Xu, Wei Huang, Han-chang Lin, Chang-jun Jiang, Zhao-Feng
- 机构：Beijing Union Univ; Beijing Union Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2010
- 关键词：Copper Neurotoxicity COSs Neuroprotective effects Oxidative damage Cortical neurons
- Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease被引量：33收藏
- 作者：Huang, Han-Chang Tang, Di Lu, Shu-Yan Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2015
- 关键词：Alzheimer's disease Endoplasmic reticulum stress Unfolded protein response Amyloid-beta peptide Calcium Inflammation
- Chitooligosaccharides Attenuate Cu2+-Induced Cellular Oxidative Damage and Cell Apoptosis Involving Nrf2 Activation被引量：32收藏
- 作者：Huang, Han-Chang Hong, Liang Chang, Ping Zhang, Jiao Lu, Shu-Yan Zheng, Bo-Wen Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2015
- 关键词：Alzheimer's disease Chitooligosaccharides Cu2+ Nrf2 Oxidative damage
- Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's disease被引量：32收藏
- 作者：Gu, Xue-Mei Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Mil Gen Hosp;Beijing Univ Chem Technol
- 来源：NEUROSCIENCE BULLETIN 2012
- 关键词：Alzheimer's disease amyloid-beta metabolic deficiency mitochondrial dysfunction
- Protection of curcumin against amyloid- b- induced cell damage and death involves the prevention from NMDA receptor- mediated intracellular Ca2+ elevation被引量：28收藏
- 作者：Huang, Han-Chang Chang, Ping Lu, Shu-Yan Zheng, Bo-Wen Jiang, Zhao-Feng
- 机构：Beijing Union Univ
- 来源：JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 2015
- 关键词：Alzheimer's disease amyloid-beta calcium curcumin neuroprotection NMDA receptor
- Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease被引量：19收藏
- 作者：Zheng, Bo-Wen Yang, Li Dai, Xue-Ling Jiang, Zhao-Feng Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2016
- 关键词：Alzheimer disease APP processing Hippocampal synapses O-GlcNAcylation Tau phosphorylation
- Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches被引量：19收藏
- 作者：Sun, Yu-Ying Wang, Zhun Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：CELLULAR AND MOLECULAR NEUROBIOLOGY 2023
- 关键词：Apolipoprotein E4 (ApoE4) Alzheimer's disease (AD) beta-Amyloid (A beta) Therapy
- Sleep-Wake Disorders in Alzheimer's Disease: A Review被引量：14收藏
- 作者：Sun, Yu-Ying Wang, Zhun Zhou, He-Yan Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2022
- 关键词：Alzheimer's disease (AD) sleep-wake disorders beta-amyloid (A beta) circadian rhythms neurotransmitters
- Modulation of A beta PP and GSK3 beta by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease被引量：14收藏
- 作者：Liu, Xin-jun Wei, Jun Shang, Ying-hui Huang, Han-chang Lao, Feng-xue
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2017
- 关键词：Alzheimer's disease amyloid-beta apoptosis endoplasmic reticulum stress neurofibrillary tangles
- Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2被引量：13收藏
- 作者：Zhou, He-Yan Sun, Yu-Ying Chang, Ping Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2022
- 关键词：Curcumin Endoplasmic reticulum stress (ERS) Mitofusin-2 (Mfn2) Mitochondrial dysfunction SH-SY5Y cells Thapsigargin
- Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway被引量：13收藏
- 作者：Zhang, Xiaoxia Liang, Shuang Gao, Xiaohan Huang, Hanchang Lao, Fengxue Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2021
- 关键词：Chitosan oligosaccharide Oxidative stress Cell apoptosis Nrf2 MAPKs
- Amyloid-beta Protein Precursor family Members: A Review from Homology to Biological Function被引量：11收藏
- 作者：Huang, Han-Chang Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Union Univ;Beijing Univ Chem Technol
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2011
- 关键词：Alzheimer's disease amyloid-beta protein precursor biological function homology structure
- Regulation of A beta PP Glycosylation Modification and Roles of Glycosylation on A beta PP Cleavage in Alzheimer's Disease被引量：11收藏
- 作者：Tao, Peng-Fei Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease amyloid-beta precursor protein protein glycosylation O-linked N-acetyl-beta-D-glucosamine transferase O-GlcNAcase
- Phosphorylation and Glycosylation of Amyloid-beta Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer's Disease被引量：10收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Yu-Ying Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2021
- 关键词：Alzheimer's disease amyloid-beta protein precursor protein glycosylation protein phosphorylation
- Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation被引量：9收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Ya-Xuan Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：MOLECULAR BIOLOGY REPORTS 2020
- 关键词：Alzheimer's disease Amyloid-beta protein precursor (APP) Amyloid-beta peptide Cell damage Hydrogen peroxide (H2O2) Curcumin Mitochondrial stress
- Independent and Correlated Role of Apolipoprotein E epsilon 4 Genotype and Herpes Simplex Virus Type 1 in Alzheimer's Disease被引量：5收藏
- 作者：Zhang, Li-Na Li, Meng-Jie Shang, Ying-Hui Zhao, Fan-Fan Huang, Han-Chang Lao, Feng-Xue
- 机构：Beijing Union Univ;Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF ALZHEIMERS DISEASE 2020
- 关键词：Alzheimer's disease apolipoprotein E cytokine estrogen therapy herpes simplex virus type 1 infectious burden interferon
- Protective Effect of Zeaxanthin against Tunicamycin-induced Cell Damage in SH-SY5Y Cell被引量：4收藏
- 作者：Wei, Jun Zhao, Fanfan Shang, YingHui Liu, Xinjun Huang, Hanchang Lao, Fengxue
- 机构：Beijing Union Univ
- 来源：FOOD SCIENCE AND TECHNOLOGY RESEARCH 2018
- 关键词：zeaxanthin endoplasmic reticulum stress tunicamycin SH-SY5Y cells Alzheimer's disease
- Magnetic Resonance Imaging of Alzheimer's Disease: from Diagnosis to Therapeutic Evaluation被引量：3收藏
- 作者：Gu Xue-mei Jiang Zhao-feng Huang Han-chang
- 机构：Beijing Mil Gen Hosp;Beijing Union Univ;Beijing Union Univ
- 来源：CHINESE JOURNAL OF INTEGRATIVE MEDICINE 2010
- 关键词：Alzheimer's disease diagnosis magnetic resonance imaging
- CHITOOLIGOSACCHARIDES ATTENUATE AMYLOID-beta-INDUCED MITOCHONDRIAL DAMAGE INVOLVED Ca2+ HOMEOSTASIS被引量：0收藏
- 作者：Lin, C. -J. Huang, H. -C. Jiang, Z. -F.
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：EUROPEAN JOURNAL OF NEUROLOGY 2011
- Cu(II) promoting amyloid beta peptide sedimentation involved in histidine residues in a non-beta aggregate way被引量：0收藏
- 作者：Jiang, Z-F. Huang, H-C. Dai, X-L.
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：EUROPEAN JOURNAL OF NEUROLOGY 2009
- Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease被引量：0收藏
- 作者：Lin, M. Yu, J. -X Zhang, W. -X Lao, F. -X Huang, H-C
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE 2024
- 关键词：Alzheimer's disease (AD) triggering receptor expressed on myeloid cells 2 (TREM2) microglia A beta monoclonal antibody
- Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function被引量：0收藏
- 作者：Yu, Jia-Xin Lin, Miao Zhang, Wen-Xuan Lao, Feng-Xue Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：CELL BIOCHEMISTRY AND FUNCTION 2024
- 关键词：apoptosis astaxanthin mitochondrial function oxidative stress oxygen consumption rate (OCR)
