文献类型：期刊文献

英文题名：Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function

作者：Yu, Jia-Xin[1];Lin, Miao[1];Zhang, Wen-Xuan[1];Lao, Feng-Xue[1];Huang, Han-Chang[1,2]

第一作者：Yu, Jia-Xin

通讯作者：Huang, HC[1];Huang, HC[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]corresponding author), Beijing Union Univ, Key Lab Nat Prod Dev & Innovat Drug Res, Beijing, Peoples R China.|[11417]北京联合大学;[114172]北京联合大学应用文理学院;[1141726]北京联合大学生物化学工程学院;

年份：2024

卷号：42

期号：8

外文期刊名：CELL BIOCHEMISTRY AND FUNCTION

收录：;Scopus(收录号：2-s2.0-85211443420);WOS:【SCI-EXPANDED(收录号:WOS:001374647100001)】；

基金：This study was supported by the Academic Research Projects of Beijing Union University (ZKZD202304 and ZK70202101).

语种：英文

外文关键词：apoptosis; astaxanthin; mitochondrial function; oxidative stress; oxygen consumption rate (OCR)

摘要：Oxidative stress (OS) is one of the factors that result in cell damage and the development of neurological diseases such as Alzheimer's disease (AD). Astaxanthin (ASTA), a natural compound known for its potent antioxidant properties, shows the biological activities in anti-apoptosis and antitumor. However, its specific mechanism on mitochondrial function remains unclear. This study investigated the effects of ASTA on regulation in mitochondrial function and cell apoptosis under OS induced by hydrogen peroxide (H2O2). The results demonstrated that ASTA (0.1, 1, 10 mu mol/L) protected cells form H2O2-induced cell damage and apoptosis through mitochondrial pathway. ASTA significantly reduced H2O2-induced mitochondrial dysfunctions and restored the intracellular reactive oxygen species (ROS), mitochondrial membrane potential, and respiratory capacity. These findings suggest that ASTA's antioxidant properties can benefit neurons by maintaining mitochondrial function and alleviating oxidative damage and cell apoptosis induced by H2O2.