成果/Result
- A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide被引量：104收藏
- 作者：Liang, Shuang Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
- 关键词：chitin chitosan chitooligosaccharide (COS) COS preparation COS analysis COS biological activity
- Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-beta(1-42)-induced rat model of Alzheimer's disease被引量：101收藏
- 作者：Jia, Shiliang Lu, Zheng Gao, Zhaolan An, Jun Wu, Xueling Li, Xiaoxiao Dai, Xueling Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2016
- 关键词：Alzheimer's disease Amyloid-beta(1-42) Chitosan oligosaccharides Oxidative stress Neuroinflammation
- Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties被引量：86收藏
- 作者：Sun, Ya-Xuan Tang, Yue Wu, Ai-Li Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Wang, Zhi-Bin
- 机构：Beijing Inst Drug Control;Beijing Union Univ;Chinese Acad Sci;Chinese Acad Med Sci;Chinese Acad Med Sci
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2010
- 关键词：liquiritin mice focal cerebral ischemia reperfusion antioxidant anti-apoptosis
- Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid beta-Mediated Neurotoxicity被引量：45收藏
- 作者：Dai, Xueling Hou, Wanqi Sun, Yaxuan Gao, Zhaolan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Capital Normal Univ;Peking Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015
- 关键词：Alzheimer's disease amyloid- peptide chitosan oligosaccharides aggregation neurotoxicity
- Acetylsalicylic acid (ASA) induced fusarium rot resistance and suppressed neosolaniol production by elevation of ROS metabolism in muskmelon fruit被引量：42收藏
- 作者：Xue Huali Sun Yaxuan Li Lan Bi Yang Hussain Raza Zhang Rui Long Haitao Nan Mina Pu Lumei
- 机构：Beijing Union Univ;Gansu Agr Univ;Gansu Agr Univ;Univ Cent Punjab
- 来源：SCIENTIA HORTICULTURAE 2020
- 关键词：Muskmelon Acetylsalicylic acid Trichothecenes ROS metabolism Fusarium rot
- Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity被引量：41收藏
- 作者：Dai, Xueling Chang, Ping Zhu, Qingzhu Liu, Wenjuan Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Peking Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2013
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides Neurotoxicity
- Copper Enhances Amyloid-beta Peptide Neurotoxicity and non beta-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-beta Peptide被引量：40收藏
- 作者：Dai, Xueling Sun, Yaxuan Gao, Zhaolan Jiang, Zhaofeng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF MOLECULAR NEUROSCIENCE 2010
- 关键词：Alzheimer's disease Amyloid-beta peptide beta aggregation Neurotoxicity
- Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-beta(1-42) oligomers injected into the hippocampus被引量：37收藏
- 作者：Jia, Shi-Liang Wu, Xue-Ling Li, Xiao-Xiao Dai, Xue-Ling Gao, Zhao-Lan Lu, Zheng Zheng, Qiu-Sheng Sun, Ya-Xuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2016
- 关键词：Liquiritin alzheimer's disease amyloid-beta(1-42) oxidative stress apoptosis
- Screening of Siderophore-Producing Bacteria and Their Effects on Promoting the Growth of Plants被引量：37收藏
- 作者：Sun, Yaxuan Wu, Juanli Shang, Xiaoya Xue, Lingui Ji, Guangyang Chang, Sijing Niu, Junbo Emaneghemi, Brown
- 机构：Beijing Union Univ;Lanzhou Jiaotong Univ;Lanzhou Jiaotong Univ
- 来源：CURRENT MICROBIOLOGY 2022
- Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia被引量：32收藏
- 作者：Sun, Ya-Xuan Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Hui, Bo-Di Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Shihezi Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2014
- 关键词：oxidative stress lutein neuroprotection antioxidant transient cerebral ischemia
- Effect of Oat Barley Powder on Glucose and Lipid Metabolism and Oxidative Stress in Type II Diabetic Mice被引量：30收藏
- 作者：Gao, Xiaohan Wang, LiguO Zhang, Shiwen Dai, Xueling Zhang, Jing Wei, Tao Mi, Shengquan Sun, Yaxuan
- 机构： Beijing Key Laboratory of Bioactive Substances and Functional Foods; Guzhen Zhangjiakou Food Co.Ltd.; Beijing Daxing Xinghua High School
- 来源：Journal of Chinese Institute of Food Science and Technology 2022
- 关键词：Blood - Glucose - Insulin - Lactic acid - Mammals - Oxidative stress - Peptides - Superoxide dismutase
- The immunometabolic reprogramming of microglia in Alzheimer's disease被引量：23收藏
- 作者：Chen, Hongli Guo, Zichen Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROCHEMISTRY INTERNATIONAL 2023
- 关键词：Microglia Immunometabolism Reprogramming Neuroinflammation Alzheimer's disease
- The Lactobacillus plantarum P-8 Probiotic Microcapsule Prevents DSS-Induced Colitis through Improving Intestinal Integrity and Reducing Colonic Inflammation in Mice被引量：14收藏
- 作者：Wang, Han Sun, Yaxuan Ma, Xuan Yang, Tianyu Wang, Feng
- 机构：Beijing Union Univ
- 来源：NUTRIENTS 2024
- 关键词：probiotic microcapsules colitis intestinal mucosal barriers inflammation NLRP3
- Chitooligosaccharide ameliorates cognitive deficits and neuroinflammation in APP/PS1 mice associated with the regulation of Nrf2/NF-κB axis被引量：14收藏
- 作者：Cai, Mingyang Zhang, Xiaoxia Gao, Xiaohan Huo, Qing Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Chitooligosaccharide Cognitive deficits Neuroinflammation Nrf2 NF-kappa B NLRP3 inflammasome
- Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-beta(1-42) Induced Alzherimer's Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry被引量：14收藏
- 作者：Liang, Shuang Wang, Zijian Yuan, Jiaqi Zhang, Jing Dai, Xueling Qin, Fei Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Union Univ;Binzhou Med Univ
- 来源：MOLECULES 2019
- 关键词：Tanshinone IIA Alzheimer's disease UHPLC-Q-Exactive Qrbitrap mass spectrometry metabolic pathway hippocampus rat model Morris water maze test passive avoidance test
- The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Li, Xiaoxiao Gao, Zhaolan Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2018
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1)
- Protective effects of fisetin in an A beta(1-42)-induced rat model of Alzheimer's disease被引量：12收藏
- 作者：Wang, Yunting Wu, Xueling Ren, Wujiang Liu, Yanxia Dai, Xueling Wang, Shuo Huo, Qing Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：FOLIA NEUROPATHOLOGICA 2023
- 关键词：Alzheimer's disease A beta(1-42) fisetin protective effects mechanism
- Rapid screening and characterization of caffeic acid metabolites in rats by UHPLC-Q-TOF mass spectrometry被引量：12收藏
- 作者：Yuan, Jiaqi Wang, Yunting Mi, Shengquan Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2021
- 关键词：Caffeic acid UHPLC-Q-TOF-MS/MS Metabolic profiling
- A beta-40 Y10F Increases beta fibrils Formation but Attenuates the Neurotoxicity of Amyloid-beta Peptide被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Liu, Wenjuan Xu, Ke Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Peking Univ;Beijing Union Univ;Capital Normal Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2012
- 关键词：Alzheimer's disease amyloid-beta peptide beta fibrils neurotoxicity
- Acetylsalicylic acid treatment reduce Fusarium rot development and neosolaniol accumulation in muskmelon fruit被引量：11收藏
- 作者：Xue Huali Bi Yang Sun Yaxuan Raza, Hussain Wang Hujun Zhang Shan Zhang Rui Long Haitao Nan Mina Cheng Xiaoyan Calderoon-Urrea, Alejandro
- 机构：Gansu Agr Univ;Gansu Agr Univ;Beijing Union Univ;Univ Cent Punjab;Gansu Agr Univ
- 来源：FOOD CHEMISTRY 2019
- 关键词：Muskmelon Fusarium sulphureum Trichothecenes ASA Fusarium rot
- Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation被引量：10收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Ya-Xuan Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：MOLECULAR BIOLOGY REPORTS 2020
- 关键词：Alzheimer's disease Amyloid-beta protein precursor (APP) Amyloid-beta peptide Cell damage Hydrogen peroxide (H2O2) Curcumin Mitochondrial stress
- Rapid Identification of 3,6 '-Disinapoyl Sucrose Metabolites in Alzheimer's Disease Model Mice Using UHPLC-Orbitrap Mass Spectrometry被引量：10收藏
- 作者：Yuan, Jiaqi Wang, Han Wang, Yunting Wang, Zijian Huo, Qing Dai, Xueling Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Binzhou Med Univ
- 来源：MOLECULES 2022
- 关键词：Alzheimer's disease 3,6 '-disinapoyl sucrose UHPLC-Orbitrap mass spectrometry metabolites metabolic pathway
- Structural and Hirshfeld Surface Analyses of a Novel Hetero-Tetranuclear Cu-II-Na-I Bis(Salamo)-Based Coordination Compound被引量：10收藏
- 作者：Sun, Ya-Xuan Liu, Ling-Zhi Wang, Fei Shang, Xiao-Ya Chen, Le Dong, Wen-Kui
- 机构：Beijing Union Univ;Lanzhou Jiaotong Univ
- 来源：CRYSTALS 2018
- 关键词：bis(Salamo)-type ligand hetero-tetranuclear Cu-II-Na-I coordination compound crystal structure hirshfeld surface analysis
- 黑果枸杞提取物活性的研究进展被引量：10收藏
- 作者：武雪玲 李筱筱 戴雪伶 孙雅煊
- 机构：北京联合大学应用文理学院;北京联合大学功能食品科学技术研究院
- 来源：《生命的化学》 2017
- 关键词：黑果枸杞 提取物 生物活性
- 摘要：黑果枸杞是一种具有良好保健功效的药食两用植物,其富含丰富的营养物质,具有多种生物活性。本文综述了黑果枸杞中花青素、多糖和甜菜碱等活性成分的性质及其保健功效的研究进展,为黑果枸杞的深入研究及进一步的开发应用提供科学依据。
- 抑郁症动物模型的建立及评价方法研究进展被引量：7收藏
- 作者：刘子轩 霍清 孙雅煊 戴雪伶 李昕
- 机构：北京联合大学生物化学工程学院
- 来源：《中国实验动物学报》 2025
- 关键词：抑郁症 动物模型 发病机制
- 摘要：抑郁症是一种常见的慢性精神疾病,抑郁症动物模型被广泛应用于抑郁症发病机制的研究和抗抑郁新药的研发,其模拟人类抑郁症状的同一性和可靠性会直接影响研究结果。然而,目前还尚未发现与人类抑郁症发病完全契合的动物模型,阻碍了对抑郁...
- 益生菌复合制剂对头孢曲松钠作用小鼠的抗氧化指标、细胞因子及肠道菌群的影响被引量：6收藏
- 作者：郭子晨 刘倩 王韵婷 王涵 赵江燕 赵雅欣 孙雅煊 戴雪伶
- 机构：北京联合大学生物化学工程学院;北京联合大学应用文理学院保健食品检测中心
- 来源：《食品工业科技》 2022
- 关键词：头孢曲松钠 长双歧杆菌BB536 乳双歧杆菌HN019 益生菌复合制剂 肠道菌群
- 摘要：目的:探究长双歧杆菌BB536和乳双歧杆菌HN019组成的益生菌复合制剂对头孢曲松钠引起的肠道菌群失调的改善效果。方法:头孢曲松钠(2 mg/g)连续灌胃小鼠5 d,构建肠道菌群失调模型小鼠,然后随机分为模型组,益生菌复...
- 壳寡糖减轻过氧化氢诱导的SK-N-SH细胞氧化损伤机制研究被引量：6收藏
- 作者：张晓霞 李筱筱 孙雅煊 戴雪伶
- 机构：北京联合大学生物化学工程学院
- 来源：《食品与发酵工业》 2021
- 关键词：壳寡糖 H2 O2 细胞凋亡 Bcl-2 Bax Nrf2 HO-1
- 摘要：为探讨壳寡糖(chitosan oligosaccharide,COS)对H_(2)O_(2)诱导的人神经母细胞瘤SK-N-SH细胞损伤的保护作用及其机制,利用H_(2)O_(2)建立体外氧化损伤模型,MTT法检测细胞存...
- 3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice被引量：5收藏
- 作者：Yuan, Jiaqi He, Mengjie Dai, Xueling Huo, Qing Chang, Ping Zhang, Jing Wang, Shuo Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF NEUROPHYSIOLOGY 2023
- 关键词：Alzheimer's disease apoptosis CREB/BDNF signal pathway 3,6'-disinapoyl sucrose Morris water maze
- 双歧杆菌二联制剂对小鼠抗氧化水平及肠道菌群的影响被引量：4收藏
- 作者：王韵婷 刘倩 郭子晨 孙雅煊 霍清 王伶毓 赵江燕
- 机构：北京联合大学生物化学工程学院;北京联合大学应用文理学院保健食品功能检测中心
- 来源：《食品科技》 2022
- 关键词：长双歧杆菌BB536 乳双歧杆菌HN019 肠道菌群 短链脂肪酸 高通量测序
- 摘要：目的:旨在探究长双歧杆菌BB536联合乳双歧杆菌HN019益生菌制剂对小鼠抗氧化水平及肠道菌群的影响,为益生菌制剂的开发利用提供依据。方法:将48只小鼠随机分为空白(Control)和低(L)、中(M)和高剂量(H)组,...
- Effects of Varied Forms of Arsenic Stress on Seedling Growth and Arsenic Distribution in Honeysuckle Plants被引量：4收藏
- 作者：Yuan, Xin Zhou, Juntong Peng, Congnan Qiao, Jiaqi Xia, Shengqi Fan, Yilin Yao, Li Qi, Kailin Chen, Dongliang Guo, Zhiying Gan, Xiaolong Sun, Yaxuan Dai, Xueling Lv, Liangyu Ji, Yizhi Huo, Qing
- 机构：Beijing Union Univ;Chinese Acad Sci;Donghua Univ
- 来源：PROCESSES 2023
- 关键词：arsenic stress honeysuckle micro X-ray fluorescence physiological indicators
