文献类型：期刊文献

英文题名：The Lactobacillus plantarum P-8 Probiotic Microcapsule Prevents DSS-Induced Colitis through Improving Intestinal Integrity and Reducing Colonic Inflammation in Mice

作者：Wang, Han[1];Sun, Yaxuan[1];Ma, Xuan[1];Yang, Tianyu[1];Wang, Feng[1]

第一作者：王宏

通讯作者：Wang, F[1]

机构：[1]Beijing Union Univ, Sch Biochem Engn, Dept Food Sci, Beijing 100023, Peoples R China

第一机构：北京联合大学生物化学工程学院食品科学系

通讯机构：[1]corresponding author), Beijing Union Univ, Sch Biochem Engn, Dept Food Sci, Beijing 100023, Peoples R China.|[11417146]北京联合大学生物化学工程学院食品科学系;[11417]北京联合大学;[1141726]生物化学工程学院;

年份：2024

卷号：16

期号：7

外文期刊名：NUTRIENTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001201545000001)】；

基金：We sincerely thank Kang Wenyi and Fathy from the National R&D Center for Edible Fungus Processing Technology, Henan University, for their meticulous editing and invaluable contributions in refining this article.

语种：英文

外文关键词：probiotic microcapsules; colitis; intestinal mucosal barriers; inflammation; NLRP3

摘要：Probiotics, recognized as beneficial and active microorganisms, often face challenges in maintaining their functionality under harsh conditions such as exposure to stomach acid and bile salts. In this investigation, we developed probiotic microcapsules and assessed their protective effects and underlying mechanisms in a murine model of dextran sulfate sodium (DSS)-induced colitis using male C57BL/6J mice. The administration of the probiotic microcapsules significantly mitigated body weight loss, prevented colon length shortening, decreased the disease activity index scores, and reduced histopathological scores in mice with DSS-induced colitis. Concurrently, the microencapsulated probiotics preserved intestinal barrier integrity by upregulating the expressions of tight junction proteins ZO-1 and occludin, as well as the mucus layer component MUC-2. Moreover, the treatment with probiotic microcapsules suppressed the activation of the NLRP3 inflammasome signaling pathway in the context of DSS-induced colitis. In conclusion, these findings support the utilization of probiotic microcapsules as a potential functional food ingredient to maintain the permeability of the intestinal barrier and alleviate colonic inflammation in UC.