文献类型：期刊文献

英文题名：Effect of Oat Barley Powder on Glucose and Lipid Metabolism and Oxidative Stress in Type II Diabetic Mice

作者：Gao, Xiaohan[1]; Wang, LiguO[2]; Zhang, Shiwen[3]; Dai, Xueling[1]; Zhang, Jing[1]; Wei, Tao[1]; Mi, Shengquan[1]; Sun, Yaxuan[1]

第一作者：Gao, Xiaohan

机构：[1] Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, China; [2] Guzhen Zhangjiakou Food Co.Ltd., Hebei, Zhangjiakou, 075000, China; [3] Beijing Daxing Xinghua High School, Beijing, 102600, China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

年份：2022

卷号：22

期号：6

起止页码：190-197

外文期刊名：Journal of Chinese Institute of Food Science and Technology

收录：EI(收录号：20223612685997)

语种：英文

外文关键词：Blood - Glucose - Insulin - Lactic acid - Mammals - Oxidative stress - Peptides - Superoxide dismutase

摘要：To investigate the effects of oat barley powder on glucose and lipid metabolism and oxidative stress in type II diabetic mice. Methods: ICR mice were fed high-fat diet combined with small dose (50 mg/kg) intraperitoneal injection of streptozotocin to establish a diabetic mouse model. The adult mice were randomly divided into a high-fat group a positive control group (metformin 200 mg/kg·d) and a high-fat oat barley powder group. Observe the changes in body weight and blood glucose of each group during the sample administration take the blood from the eyeball after 6 weeks of sample administration and detect blood lipids fasting blood sugar and serum insulin. The liver tissue was collected to determine the activity of malonaldehyde (MDA) superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activity and glutathione(GSH). Results: Compared with the high-fat group the high-fat oat barley powder group can effectively alleviate the symptoms of diabetic mice. HE staining showed that oat barley powder improved the pathological state of the mouse pancreas it could significantly reduce the fasting blood glucose level of type II diabetic mice (P0.05) and it has a significant effect on TC reduction (P0.05). Compared with the high-fat group the high-fat oat barley powder group had a very significant increase in serum insulin (P ? 2022 Chinese Institute of Food Science and Technology. All rights reserved.