成果/Result
- A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide被引量：104收藏
- 作者：Liang, Shuang Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
- 关键词：chitin chitosan chitooligosaccharide (COS) COS preparation COS analysis COS biological activity
- Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-beta(1-42)-induced rat model of Alzheimer's disease被引量：92收藏
- 作者：Jia, Shiliang Lu, Zheng Gao, Zhaolan An, Jun Wu, Xueling Li, Xiaoxiao Dai, Xueling Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2016
- 关键词：Alzheimer's disease Amyloid-beta(1-42) Chitosan oligosaccharides Oxidative stress Neuroinflammation
- Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties被引量：86收藏
- 作者：Sun, Ya-Xuan Tang, Yue Wu, Ai-Li Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Wang, Zhi-Bin
- 机构：Beijing Inst Drug Control;Beijing Union Univ;Chinese Acad Sci;Chinese Acad Med Sci;Chinese Acad Med Sci
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2010
- 关键词：liquiritin mice focal cerebral ischemia reperfusion antioxidant anti-apoptosis
- Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid beta-Mediated Neurotoxicity被引量：45收藏
- 作者：Dai, Xueling Hou, Wanqi Sun, Yaxuan Gao, Zhaolan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Capital Normal Univ;Peking Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015
- 关键词：Alzheimer's disease amyloid- peptide chitosan oligosaccharides aggregation neurotoxicity
- Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity被引量：41收藏
- 作者：Dai, Xueling Chang, Ping Zhu, Qingzhu Liu, Wenjuan Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Peking Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2013
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides Neurotoxicity
- Copper Enhances Amyloid-beta Peptide Neurotoxicity and non beta-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-beta Peptide被引量：40收藏
- 作者：Dai, Xueling Sun, Yaxuan Gao, Zhaolan Jiang, Zhaofeng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF MOLECULAR NEUROSCIENCE 2010
- 关键词：Alzheimer's disease Amyloid-beta peptide beta aggregation Neurotoxicity
- Acetylsalicylic acid (ASA) induced fusarium rot resistance and suppressed neosolaniol production by elevation of ROS metabolism in muskmelon fruit被引量：38收藏
- 作者：Xue Huali Sun Yaxuan Li Lan Bi Yang Hussain Raza Zhang Rui Long Haitao Nan Mina Pu Lumei
- 机构：Beijing Union Univ;Gansu Agr Univ;Gansu Agr Univ;Univ Cent Punjab
- 来源：SCIENTIA HORTICULTURAE 2020
- 关键词：Muskmelon Acetylsalicylic acid Trichothecenes ROS metabolism Fusarium rot
- Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-beta(1-42) oligomers injected into the hippocampus被引量：35收藏
- 作者：Jia, Shi-Liang Wu, Xue-Ling Li, Xiao-Xiao Dai, Xue-Ling Gao, Zhao-Lan Lu, Zheng Zheng, Qiu-Sheng Sun, Ya-Xuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2016
- 关键词：Liquiritin alzheimer's disease amyloid-beta(1-42) oxidative stress apoptosis
- Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia被引量：32收藏
- 作者：Sun, Ya-Xuan Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Hui, Bo-Di Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Shihezi Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2014
- 关键词：oxidative stress lutein neuroprotection antioxidant transient cerebral ischemia
- Screening of Siderophore-Producing Bacteria and Their Effects on Promoting the Growth of Plants被引量：29收藏
- 作者：Sun, Yaxuan Wu, Juanli Shang, Xiaoya Xue, Lingui Ji, Guangyang Chang, Sijing Niu, Junbo Emaneghemi, Brown
- 机构：Beijing Union Univ;Lanzhou Jiaotong Univ;Lanzhou Jiaotong Univ
- 来源：CURRENT MICROBIOLOGY 2022
- The immunometabolic reprogramming of microglia in Alzheimer's disease被引量：15收藏
- 作者：Chen, Hongli Guo, Zichen Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROCHEMISTRY INTERNATIONAL 2023
- 关键词：Microglia Immunometabolism Reprogramming Neuroinflammation Alzheimer's disease
- Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-beta(1-42) Induced Alzherimer's Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry被引量：13收藏
- 作者：Liang, Shuang Wang, Zijian Yuan, Jiaqi Zhang, Jing Dai, Xueling Qin, Fei Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Union Univ;Binzhou Med Univ
- 来源：MOLECULES 2019
- 关键词：Tanshinone IIA Alzheimer's disease UHPLC-Q-Exactive Qrbitrap mass spectrometry metabolic pathway hippocampus rat model Morris water maze test passive avoidance test
- The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Li, Xiaoxiao Gao, Zhaolan Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2018
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1)
- A beta-40 Y10F Increases beta fibrils Formation but Attenuates the Neurotoxicity of Amyloid-beta Peptide被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Liu, Wenjuan Xu, Ke Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Peking Univ;Beijing Union Univ;Capital Normal Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2012
- 关键词：Alzheimer's disease amyloid-beta peptide beta fibrils neurotoxicity
- Acetylsalicylic acid treatment reduce Fusarium rot development and neosolaniol accumulation in muskmelon fruit被引量：11收藏
- 作者：Xue Huali Bi Yang Sun Yaxuan Raza, Hussain Wang Hujun Zhang Shan Zhang Rui Long Haitao Nan Mina Cheng Xiaoyan Calderoon-Urrea, Alejandro
- 机构：Gansu Agr Univ;Gansu Agr Univ;Beijing Union Univ;Univ Cent Punjab;Gansu Agr Univ
- 来源：FOOD CHEMISTRY 2019
- 关键词：Muskmelon Fusarium sulphureum Trichothecenes ASA Fusarium rot
- Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation被引量：10收藏
- 作者：Song, Xi-Jun Zhou, He-Yan Sun, Ya-Xuan Huang, Han-Chang
- 机构：Beijing Union Univ
- 来源：MOLECULAR BIOLOGY REPORTS 2020
- 关键词：Alzheimer's disease Amyloid-beta protein precursor (APP) Amyloid-beta peptide Cell damage Hydrogen peroxide (H2O2) Curcumin Mitochondrial stress
- Rapid Identification of 3,6 '-Disinapoyl Sucrose Metabolites in Alzheimer's Disease Model Mice Using UHPLC-Orbitrap Mass Spectrometry被引量：10收藏
- 作者：Yuan, Jiaqi Wang, Han Wang, Yunting Wang, Zijian Huo, Qing Dai, Xueling Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Binzhou Med Univ
- 来源：MOLECULES 2022
- 关键词：Alzheimer's disease 3,6 '-disinapoyl sucrose UHPLC-Orbitrap mass spectrometry metabolites metabolic pathway
- Structural and Hirshfeld Surface Analyses of a Novel Hetero-Tetranuclear Cu-II-Na-I Bis(Salamo)-Based Coordination Compound被引量：10收藏
- 作者：Sun, Ya-Xuan Liu, Ling-Zhi Wang, Fei Shang, Xiao-Ya Chen, Le Dong, Wen-Kui
- 机构：Beijing Union Univ;Lanzhou Jiaotong Univ
- 来源：CRYSTALS 2018
- 关键词：bis(Salamo)-type ligand hetero-tetranuclear Cu-II-Na-I coordination compound crystal structure hirshfeld surface analysis
- Rapid screening and characterization of caffeic acid metabolites in rats by UHPLC-Q-TOF mass spectrometry被引量：7收藏
- 作者：Yuan, Jiaqi Wang, Yunting Mi, Shengquan Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2021
- 关键词：Caffeic acid UHPLC-Q-TOF-MS/MS Metabolic profiling
- Protective effects of fisetin in an A beta(1-42)-induced rat model of Alzheimer's disease被引量：6收藏
- 作者：Wang, Yunting Wu, Xueling Ren, Wujiang Liu, Yanxia Dai, Xueling Wang, Shuo Huo, Qing Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：FOLIA NEUROPATHOLOGICA 2023
- 关键词：Alzheimer's disease A beta(1-42) fisetin protective effects mechanism
- The Lactobacillus plantarum P-8 Probiotic Microcapsule Prevents DSS-Induced Colitis through Improving Intestinal Integrity and Reducing Colonic Inflammation in Mice被引量：5收藏
- 作者：Wang, Han Sun, Yaxuan Ma, Xuan Yang, Tianyu Wang, Feng
- 机构：Beijing Union Univ
- 来源：NUTRIENTS 2024
- 关键词：probiotic microcapsules colitis intestinal mucosal barriers inflammation NLRP3
- 3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice被引量：5收藏
- 作者：Yuan, Jiaqi He, Mengjie Dai, Xueling Huo, Qing Chang, Ping Zhang, Jing Wang, Shuo Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF NEUROPHYSIOLOGY 2023
- 关键词：Alzheimer's disease apoptosis CREB/BDNF signal pathway 3,6'-disinapoyl sucrose Morris water maze
- Research Progress in the Analysis of Chemical Forms of Mercury in Traditional Chinese Medicine被引量：3收藏
- 作者：Peng, Congnan Kang, Liping Yuan, Xin Qiao, Jiaqi Fan, Yilin Yao, Li Qi, Kailin Sun, Yaxuan Dai, Xueling Zhang, Yuan Huo, Qing
- 机构：Beijing Union Univ;China Acad Chinese Med Sci
- 来源：PROCESSES 2023
- 关键词：analysis of chemical state mercury research progress traditional Chinese medicine
- Chitooligosaccharide ameliorates cognitive deficits and neuroinflammation in APP/PS1 mice associated with the regulation of Nrf2/NF-κB axis被引量：3收藏
- 作者：Cai, Mingyang Zhang, Xiaoxia Gao, Xiaohan Huo, Qing Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Chitooligosaccharide Cognitive deficits Neuroinflammation Nrf2 NF-kappa B NLRP3 inflammasome
- Effects of Tanshinone IIA on Cognitive Impairment in Alzheimer's Disease Rats Via Oxidative Stress, Inflammatory Responses and Apoptosis被引量：2收藏
- 作者：Ren, Wujiang Li, Xiaoxiao Wang, Tingqiao Liu, Yanxia Dai, Xueling Huo, Qing Wang, Shuo Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ;Binzhou Med Univ
- 来源：PHARMACOGNOSY MAGAZINE 2024
- 关键词：Tanshinone IIA cognitive impairment oxidative stress inflammation Alzheimer's disease
- Study on arsenic speciation and redistribution mechanism in Lonicera japonica plants via synchrotron techniques被引量：2收藏
- 作者：Qiao, Jiaqi Zhou, Juntong Peng, Congnan Yuan, Xin Yao, Li Fan, Yilin Qi, Kailin Chen, Dongliang Guo, Zhiying Gan, Xiaolong Sun, Yaxuan Dai, Xueling Wu, Guohao Huo, Qing
- 机构：Beijing Union Univ;Chinese Acad Sci;Sci Res Inst Beijing Tongrentang Co Ltd;Beijing Union Univ
- 来源：OPEN CHEMISTRY 2023
- 关键词：arsenic speciation Lonicera japonica dimethyl arsenate acid synchrotron X-ray fluorescence spectroscopy correlation analysis
- 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway被引量：2收藏
- 作者：Wang, Yun-Ting Wang, Han Ren, Wu-Jiang Dai, Xue-Ling Huo, Qing Wang, Shuo Sun, Ya-Xuan
- 机构：Beijing Union Univ;Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 0
- 关键词：Alzheimer's disease BDNF TrkB LPS neuroinflammation
- Study on the speciation of arsenic in the genuine medicinal material honeysuckle被引量：1收藏
- 作者：Peng, Congnan Zhou, Juntong Sun, Yaxuan Yin, Hang Chen, Yuxin Yao, Li Qi, Kailin Huo, Qing Xie, Fei
- 机构：Beijing Union Univ
- 来源：OPEN CHEMISTRY 2021
- 关键词：honeysuckle speciation of arsenic HPLC-ICP-MS
- Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice被引量：1收藏
- 作者：He, Mengjie Hu, Mengying Wang, Tingqiao Zuo, Zeping Li, Hongkai Zhao, Zhiwei Hao, Yunwen Dai, Xueling Wang, Jianfang Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Tongrentang Co Ltd;Univ British Columbia;Beijing Univ Chinese Med
- 来源：FRONTIERS IN NEUROSCIENCE 2025
- 关键词：
Morinda officinalis oligosaccharides depression CUMS BDNF/TrkB/CREB pathway gut microbiota sexual dysfunction
- Chitosan Oligosaccharide Attenuates Neuroinflammation by Regulating Microglial Immunometabolic Reprogramming via the mTOR Signaling Pathway被引量：0收藏
- 作者：Chen, Hongli Cai, Mingyang He, Yue Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：microglia chitosan oligosaccharide (COS) neuroinflammation immunometabolic reprogramming M2 polarization oxidative phosphorylation (OXPHOS) mTOR signaling pathway
