文献类型：期刊文献

英文题名：Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

作者：He, Mengjie[1];Hu, Mengying[2];Wang, Tingqiao[1];Zuo, Zeping[3];Li, Hongkai[3];Zhao, Zhiwei[3];Hao, Yunwen[4];Dai, Xueling[1];Wang, Jianfang[5];Sun, Yaxuan[1]

第一作者：He, Mengjie

通讯作者：Sun, YX[1];Wang, JF[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing, Peoples R China;[2]Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China;[3]Beijing Tongrentang Co Ltd, Beijing, Peoples R China;[4]Univ British Columbia, Fac Land & Food Syst, Vancouver, BC, Canada;[5]Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing, Peoples R China;[2]corresponding author), Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2025

卷号：18

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001401291700001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by the State Administration for Market Regulation Science and Technology Plan Project, No. 2023MK215; National Science and Technology Major Project, No. 2014ZX09301307.

语种：英文

外文关键词：Morinda officinalis oligosaccharides; depression; CUMS; BDNF/TrkB/CREB pathway; gut microbiota; sexual dysfunction

摘要：Background In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.Methods Chronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.Results The results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. MOO further confirmed that sexual dysfunction is closely related to the development of depression by improving the lack of sexual motivation and low sexual performance in CUMS-induced depressed mice, modulating the disruption of sex hormone secretion in serum, and alleviating sperm morphology and functional defects in the epididymis.Conclusion These findings on MOO provide a basis for exploring its antidepressant mechanism, its use to improve hypogonadotropic symptoms, and for future development of new antidepressant drug to improves hypogonadotropic symptoms.