文献类型：期刊文献

英文题名：3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

作者：Wang, Yun-Ting[1,2];Wang, Han[2];Ren, Wu-Jiang[2];Dai, Xue-Ling[1];Huo, Qing[2];Wang, Shuo[3];Sun, Ya-Xuan[1]

第一作者：Wang, Yun-Ting

通讯作者：Sun, YX[1]

机构：[1]Beijing Union Univ, Inst Funct Food Sci & Technol, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[2]Beijing Union Univ, Sch Biochem Engn, Dept Food Sci, Beijing 100191, Peoples R China;[3]Nankai Univ, Dept Food Sci, Sch Med, Tianjin 300350, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Inst Funct Food Sci & Technol, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：0

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;Scopus(收录号：2-s2.0-85131527029);WOS:【SCI-EXPANDED(收录号:WOS:000807642800001)】；

基金：National Natural Science Foundation of China [grant number 11975048]; Beijing Union University Open Project [grant number SWHX202103]; Beijing Union University Scientific Research Project Funding [grant number XP202007].

语种：英文

外文关键词：Alzheimer's disease; BDNF; TrkB; LPS; neuroinflammation

摘要：The aim of this study is to explore the effect and mechanism of 3,6'-disinapoylsucrose (DISS) on an Alzheimer's disease (AD) mice model induced by APPswe695 lentivirus (LV) and intraperitoneal injection of lipopolysaccharide (LPS). The results show that DISS improves cognitive ability, decreases the levels of IL-2, IL-6, IL-1 beta, and TNF-alpha, reduces the expression of NF-kappa B p65, and alleviates A beta deposition and nerve cell damage. DISS can regulate tyrosine kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus. In summary, DISS can significantly alleviate neuroinflammation, spatial learning and memory disorders in AD model mice.