- High Production of 3-Hydroxypropionic Acid in Klebsiella pneumoniae by Systematic Optimization of Glycerol Metabolism被引量：73收藏
- 作者：Li, Ying Wang, Xi Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：SCIENTIFIC REPORTS 2016
- Isolation and characterization of a novel bacterium: Pseudomonas aeruginosa for biofertilizer production from kitchen waste oil被引量：43收藏
- 作者：Li, Ying Cui, Ting Wang, Yaxin Ge, Xizhen
- 机构： Beijing Key Laboratory of Biomass Waste Resource Utilization
- 来源：RSC Advances 2018
- 关键词：Degradation - Mass spectrometry - Kitchens - Biodegradation - Fatty acids - Gas chromatography - Oils and fats - Cultivation
- 科学与思政视角的屠呦呦与青蒿素被引量：41收藏
- 作者：葛喜珍 李映 韩永萍 杜凤翔 刘红梅
- 机构：北京联合大学生物化学工程学院
- 来源：《教育教学论坛》 2020
- 关键词：青蒿素 思政 屠呦呦
- 摘要：屠呦呦因发现青蒿素治疗疟疾的全新治疗方法而获得2015年诺贝尔生理或医学奖。屠呦呦发现青蒿素经历13年,聚集全国60多个科研单位,参加项目的工作人员达五六百人,研发过程折射出屠呦呦团队科学研究的专注、执着和恒心,同时也体...
- Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies被引量：31收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：MICROBIOLOGY SPECTRUM 2023
- 关键词：berberine efflux pump inhibitor salt bridge conformational transition
- Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis被引量：30收藏
- 作者：Wang, Jingxuan Zhao, Peng Li, Ying Xu, Lida Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：MICROBIAL CELL FACTORIES 2018
- 关键词：CRISPR interference Klebsiella pneumoniae 3-Hydroxypropionic acid Lactic acid Lactate dehydrogenase
- Evaluation of berberine as a natural fungicide: biodegradation and antimicrobial mechanism被引量：29收藏
- 作者：Li, Ying Yin, Yi-Ming Wang, Xin-Yue Wu, Hao Ge, Xi-Zhen
- 机构：Beijing Union Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2018
- 关键词：Berberine antimicrobial mechanism glucan bacterial diversity degradation
- Multipath effects of berberine on peach Brown rot fungus Monilinia fructicola被引量：28收藏
- 作者：Pei, Qinghui Li, Ying Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：CROP PROTECTION 2019
- 关键词：Monilinia fructicola Peach brown rot Berberine Transcriptomic analysis
- Hormesis Effect of Berberine against Klebsiella pneumoniae Is Mediated by Up-Regulation of the Efflux Pump KmrA被引量：23收藏
- 作者：Li, Ying Wen, Honglin Ge, Xizhen
- 机构：Beijing Union Univ;Capital Med Univ
- 来源：JOURNAL OF NATURAL PRODUCTS 2021
- 夏至草、益母草及夏枯草的化学成分及药理作用研究进展被引量：21收藏
- 作者：杨慧珍 李映 葛喜珍
- 机构：北京联合大学生物化学工程学院
- 来源：《北京联合大学学报》 2021
- 关键词：夏至草 益母草 夏枯草 化学成分 药理作用
- 摘要：夏至草、益母草和夏枯草均为唇形科植物,功效类似,植物形态相似,有共有和特有的化学成分,包括生物碱、萜类、黄酮类、甾体类、苯乙醇苷类、挥发油、木脂素、香豆素、蒽醌等,其主要化学成分具有改善血液微循环障碍、抗炎抗氧化、心肌保...
- Analysis of AcrB in Klebsiella pneumoniae reveals natural variants promoting enhanced multidrug resistance被引量：15收藏
- 作者：Li, Ying Cross, Trevor S. Dorr, Tobias
- 机构：Cornell Univ;Beijing Union Univ;Cornell Univ
- 来源：RESEARCH IN MICROBIOLOGY 2022
- 关键词：AcrAB Efflux pump Resistance-nodulation-cell division Antibiotic resistance
- 制药设备与车间设计课程教学改革与探索被引量：14收藏
- 作者：韩永萍 刘红梅 李可意 葛喜珍 李映
- 机构：北京联合大学生物化学工程学院
- 来源：《中国现代教育装备》 2019
- 关键词：制药设备与车间设计 现代信息技术 学科竞赛 教学改革
- 摘要：针对制药设备与车间设计课程教学内容与实际应用差距大、学时少、实践教学环节薄弱、药工脱节严重等普遍问题,基于现代信息技术及学科竞赛,从教学内容、教学方法及教学团队建设3个方面提出课程改革建议,为新形势下的制药设备与车间设计...
- 间作模式对黄精产量及种植效益的影响被引量：13收藏
- 作者：崔瑶 李映 和润莹 王占民 葛喜珍
- 机构：北京联合大学生物化学工程学院;安国祁安药业有限公司
- 来源：《湖南农业科学》 2023
- 关键词：黄精 烟草 玉米 白蜡树 间作 产量 效益
- 摘要：为了提高北方地区黄精栽培收益,以黄精单作+覆盖遮阳网为对照,以烤烟、玉米、白蜡树与黄精间作为处理,连续4 a调查黄精成活率、株高和病虫害发生情况,第4年收获黄精时,检测土壤酶活性,调查黄精及间作作物的产量及综合产值,从而...
- 绿原酸的生物活性及其作为食品添加剂的应用潜力探讨被引量：12收藏
- 作者：和润莹 杨慧珍 崔瑶 李映 葛喜珍
- 机构：北京联合大学生物化学工程学院
- 来源：《中国食品添加剂》 2022
- 关键词：绿原酸 生物活性 应用前景 食品添加剂
- 摘要：绿原酸是植物在有氧呼吸过程中经莽草酸途径形成的苯丙素类化合物,是人类饮食中含量最丰富、功能最强的多酚化合物之一。绿原酸可改善人类健康、提高食品营养和延长食品保质期,在食品添加剂领域有较大的应用潜力。本文综述了绿原酸的抗肥...
- Lignocellulose mulch increases the economic benefit of Chinese chestnut by suppressing weed and ameliorating soil properties被引量：12收藏
- 作者：Tian, Geran Li, Ying
- 机构：Univ Int Business & Econ;Beijing Union Univ
- 来源：SCIENTIA HORTICULTURAE 2022
- 关键词：Chinese chestnut Lignocellulose mulch Weed suppression Soil diversity Economic benefit
- 沉香的质量标志物预测与指纹图谱分析验证被引量：11收藏
- 作者：杨慧珍 和润莹 李映 葛喜珍
- 机构：北京联合大学生物化学工程学院
- 来源：《中国现代应用药学》 2022
- 关键词：沉香 指纹图谱 网络药理学 质量标志物
- 摘要：目的寻找沉香药材的质量标志物。方法通过网络药理学初步筛选出沉香的潜在质量标志物,进一步采用HPLC建立13批不同产地沉香药材的指纹图谱。对13批沉香药材运用主成分分析(principal component analys...
- 酶法自茶叶中提取茶多酚工艺和口味研究被引量：10收藏
- 作者：李映 陈佳芸 吴亚楠 闻雪畅 葛喜珍
- 机构：北京联合大学生物化学工程学院
- 来源：《北京联合大学学报》 2020
- 关键词：茶叶 茶叶渣 茶多酚 口味
- 摘要：目的:探讨酶法对茶叶和茶叶渣中茶多酚提取效果及口味的影响。方法:设计单因素及正交试验,使用纤维素酶和果胶酶酶解茶叶和茶叶渣,紫外分光光度法和HPLC法检测茶多酚含量,HPLC法检测氨基酸含量,评价提取液口味。结果:酶法提...
- Isolation and characterization of a novel bacterium Pseudomonas aeruginosa for biofertilizer production from kitchen waste oil被引量：9收藏
- 作者：Li, Ying Cui, Ting Wang, Yaxin Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：RSC ADVANCES 2018
- 关键词：Agricultural robots - Bacteria - Biodegradation - Cultivation - Degradation - Fatty acids - Fertilizers - Gas chromatography - Kitchens - Mass spectrometry - Petroleum industry - Probiotics
- Saprophytic Bacillus Accelerates the Release of Effective Components in Agarwood by Degrading Cellulose被引量：8收藏
- 作者：Yang, Huizhen He, Runying Cui, Yao Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：MOLECULES 2022
- 关键词：saprophytic Bacillus Agarwood cellulose effective components
- 五种中药材乙醇提取物对植物病原真菌的抑制作用研究被引量：7收藏
- 作者：裴庆慧 王玥 刘宇莹 田平芳 李映 葛喜珍
- 机构：北京联合大学生物化学工程学院;北京化工大学生命科学与技术学院;生物质废弃物资源化利用北京市重点实验室
- 来源：《食品工业科技》 2016
- 关键词：中药材提取物 植物病原真菌 抑菌
- 摘要：本文研究了山豆根、白头翁、紫花地丁、穿心莲和青皮五种中药材提取物对桃褐腐病、马铃薯干腐病、甘蓝枯萎病、番茄灰霉病、小麦赤霉病、苹果轮纹病及棉花枯萎病等七种病原菌的抑制作用。结果表明除甘蓝枯萎病外,山豆根、青皮、穿心莲提取...
- Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity被引量：7收藏
- 作者：Li, Ying Wei, Jinqing Yang, Huizhen Dai, Jing Ge, Xizhen
- 机构：Beijing Union Univ;Beijing Aerosp Petrochem EC & EP Technol Co Ltd
- 来源：PLOS ONE 2021
- Co-production of 1,3-Propanediol and 2,3-Butanediol from Waste Lard by Co-cultivation of Pseudomonas alcaligenes and Klebsiella pneumoniae被引量：7收藏
- 作者：Li, Ying Zhu, Siyu Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：CURRENT MICROBIOLOGY 2019
- Discovering interrelated natural mutations of efflux pump KmrA from Klebsiella pneumoniae that confer increased multidrug resistance被引量：7收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：PROTEIN SCIENCE 2022
- 关键词：efflux pump Klebsiella pneumoniae major facilitator superfamily molecular dynamics
- Molecular Dynamics Investigation of MFS Efflux Pump MdfA Reveals an Intermediate State between Its Inward and Outward Conformations被引量：7收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
- 关键词：major facilitator superfamily efflux pump conformational transition intermediate state molecular dynamics
- Identification of a novel hydrolase encoded by hy-1 from Bacillus amyloliquefaciens for bioremediation of carbendazim contaminated soil and food被引量：6收藏
- 作者：Li, Ying Chi, Miaomiao Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING 2019
- 关键词：carbendazim bioremediation antifungal and antibacterial pesticide hydrolase soil food pesticide contamination
- Expression of the TetA gene encoding TetA efflux protein in E. coli contributes to its increased bacterial resistance toward berberine被引量：6收藏
- 作者：Li, Ying Cao, Zhe-Tong Wang, Xin-Yue Ge, Xi-Zhen
- 机构：Beijing Union Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2018
- 关键词：TetA efflux protein berberine bacterial resistance tetracycline EC50
- Natural compound berberine inhibits apple ring rot fungus Botryosphaeria dothidea被引量：6收藏
- 作者：Li, Pengyu Liu, Jinrong Li, Ying Yang, Tao Ge, Xizhen Tian, Pingfang
- 机构：Beijing Union Univ;Beijing Univ Chem Technol
- 来源：INTERNATIONAL JOURNAL OF PEST MANAGEMENT 0
- 关键词：Apple ring rot berberine Botryosphaeria dothidea enzyme activity inhibition rate
- Enhanced internal ionic interaction of MFS efflux pump MdfA contributes to its elevated antibiotic export被引量：5收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 0
- Regulatory mechanism of fermented wheat germ on lipid metabolism in hyperlipidemia rats via activation of AMPK pathway被引量：5收藏
- 作者：Mi, Shengquan Gu, Junxia Cao, Xuelian Li, Yi Xu, Qile Chen, Wen Zhang, Yanzhen
- 机构：Beijing Union Univ;Beijing Key Lab Bioact Subst & Funct Foods
- 来源：FOOD SCIENCE AND TECHNOLOGY 2022
- 关键词：fermented wheat germ lipid metabolism hyperlipidemia AMPK
- Production of 1,3-propanediol from glycerol using a new isolate Klebsiella sp AA405 carrying low levels of virulence factors被引量：5收藏
- 作者：Li, Ying Ge, Xi-Zhen Tian, Ping-Fang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 2017
- 关键词：Klebsiella pneumoniae virulence factor endotoxin 1,3-propanediol 2,3-butanediol
- Development of a Red recombinase system and antisense RNA technology in Klebsiella pneumoniae for the production of chemicals被引量：5收藏
- 作者：Li, Ying Li, Sha Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：RSC ADVANCES 2016
- 关键词：Acetic acid - Escherichia coli - Genes - Genetic engineering - Glycerol - Lactic acid - Metabolism - pH
