成果/Result
- A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide被引量：100收藏
- 作者：Liang, Shuang Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
- 关键词：chitin chitosan chitooligosaccharide (COS) COS preparation COS analysis COS biological activity
- Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties被引量：86收藏
- 作者：Sun, Ya-Xuan Tang, Yue Wu, Ai-Li Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Wang, Zhi-Bin
- 机构：Beijing Inst Drug Control;Beijing Union Univ;Chinese Acad Sci;Chinese Acad Med Sci;Chinese Acad Med Sci
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2010
- 关键词：liquiritin mice focal cerebral ischemia reperfusion antioxidant anti-apoptosis
- Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-beta(1-42)-induced rat model of Alzheimer's disease被引量：80收藏
- 作者：Jia, Shiliang Lu, Zheng Gao, Zhaolan An, Jun Wu, Xueling Li, Xiaoxiao Dai, Xueling Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2016
- 关键词：Alzheimer's disease Amyloid-beta(1-42) Chitosan oligosaccharides Oxidative stress Neuroinflammation
- Protective Effects of Curcumin on Amyloid-beta-Induced Neuronal Oxidative Damage被引量：42收藏
- 作者：Huang, Han-Chang Chang, Ping Dai, Xue-Ling Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：NEUROCHEMICAL RESEARCH 2012
- 关键词：Alzheimer's disease (AD) Amyloid-beta (A beta) Curcumin Molecular interaction Oxidative damage
- Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid beta-Mediated Neurotoxicity被引量：41收藏
- 作者：Dai, Xueling Hou, Wanqi Sun, Yaxuan Gao, Zhaolan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Capital Normal Univ;Peking Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015
- 关键词：Alzheimer's disease amyloid- peptide chitosan oligosaccharides aggregation neurotoxicity
- Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity被引量：39收藏
- 作者：Dai, Xueling Chang, Ping Zhu, Qingzhu Liu, Wenjuan Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Peking Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2013
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides Neurotoxicity
- Copper Enhances Amyloid-beta Peptide Neurotoxicity and non beta-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-beta Peptide被引量：38收藏
- 作者：Dai, Xueling Sun, Yaxuan Gao, Zhaolan Jiang, Zhaofeng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF MOLECULAR NEUROSCIENCE 2010
- 关键词：Alzheimer's disease Amyloid-beta peptide beta aggregation Neurotoxicity
- Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-beta(1-42) oligomers injected into the hippocampus被引量：31收藏
- 作者：Jia, Shi-Liang Wu, Xue-Ling Li, Xiao-Xiao Dai, Xue-Ling Gao, Zhao-Lan Lu, Zheng Zheng, Qiu-Sheng Sun, Ya-Xuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2016
- 关键词：Liquiritin alzheimer's disease amyloid-beta(1-42) oxidative stress apoptosis
- Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia被引量：27收藏
- 作者：Sun, Ya-Xuan Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Hui, Bo-Di Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Shihezi Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2014
- 关键词：oxidative stress lutein neuroprotection antioxidant transient cerebral ischemia
- Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease被引量：17收藏
- 作者：Zheng, Bo-Wen Yang, Li Dai, Xue-Ling Jiang, Zhao-Feng Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2016
- 关键词：Alzheimer disease APP processing Hippocampal synapses O-GlcNAcylation Tau phosphorylation
- Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-beta(1-42) Induced Alzherimer's Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry被引量：13收藏
- 作者：Liang, Shuang Wang, Zijian Yuan, Jiaqi Zhang, Jing Dai, Xueling Qin, Fei Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Union Univ;Binzhou Med Univ
- 来源：MOLECULES 2019
- 关键词：Tanshinone IIA Alzheimer's disease UHPLC-Q-Exactive Qrbitrap mass spectrometry metabolic pathway hippocampus rat model Morris water maze test passive avoidance test
- Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway被引量：13收藏
- 作者：Zhang, Xiaoxia Liang, Shuang Gao, Xiaohan Huang, Hanchang Lao, Fengxue Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2021
- 关键词：Chitosan oligosaccharide Oxidative stress Cell apoptosis Nrf2 MAPKs
- A beta-40 Y10F Increases beta fibrils Formation but Attenuates the Neurotoxicity of Amyloid-beta Peptide被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Liu, Wenjuan Xu, Ke Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Peking Univ;Beijing Union Univ;Capital Normal Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2012
- 关键词：Alzheimer's disease amyloid-beta peptide beta fibrils neurotoxicity
- The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells被引量：11收藏
- 作者：Dai, Xueling Chang, Ping Li, Xiaoxiao Gao, Zhaolan Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2018
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1)
- Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of beta-amyloid peptide被引量：8收藏
- 作者：Zhang, Jian-Xiang Lai, Yi-Hui Mi, Pan-Ying Dai, Xue-Ling Zhang, Ran Zhang, Zhan-Jun Zhang, Shu-Juan Zhang, Xi-Wen Zhang, Xi-Yan Yang, Bing-Yu Cui, Dong-Mei Zhang, Chen Zhao, Chang-Qi Dou, Fei
- 机构：Beijing Normal Univ;Beijing Union Univ;Beijing Normal Univ;Peking Univ;161 Middle Sch
- 来源：ALZHEIMERS RESEARCH & THERAPY 2019
- 关键词：Alzheimer's disease beta-Amyloid Oligomers Globulomers Flavonoid
- Rapid Identification of 3,6 '-Disinapoyl Sucrose Metabolites in Alzheimer's Disease Model Mice Using UHPLC-Orbitrap Mass Spectrometry被引量：6收藏
- 作者：Yuan, Jiaqi Wang, Han Wang, Yunting Wang, Zijian Huo, Qing Dai, Xueling Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Binzhou Med Univ
- 来源：MOLECULES 2022
- 关键词：Alzheimer's disease 3,6 '-disinapoyl sucrose UHPLC-Orbitrap mass spectrometry metabolites metabolic pathway
- Protective effects of fisetin in an A beta(1-42)-induced rat model of Alzheimer's disease被引量：5收藏
- 作者：Wang, Yunting Wu, Xueling Ren, Wujiang Liu, Yanxia Dai, Xueling Wang, Shuo Huo, Qing Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：FOLIA NEUROPATHOLOGICA 2023
- 关键词：Alzheimer's disease A beta(1-42) fisetin protective effects mechanism
- 3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway被引量：2收藏
- 作者：Wang, Yun-Ting Wang, Han Ren, Wu-Jiang Dai, Xue-Ling Huo, Qing Wang, Shuo Sun, Ya-Xuan
- 机构：Beijing Union Univ;Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 0
- 关键词：Alzheimer's disease BDNF TrkB LPS neuroinflammation
- The immunometabolic reprogramming of microglia in Alzheimer's disease被引量：2收藏
- 作者：Chen, Hongli Guo, Zichen Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROCHEMISTRY INTERNATIONAL 2023
- 关键词：Microglia Immunometabolism Reprogramming Neuroinflammation Alzheimer's disease
- Study on arsenic speciation and redistribution mechanism in Lonicera japonica plants via synchrotron techniques被引量：1收藏
- 作者：Qiao, Jiaqi Zhou, Juntong Peng, Congnan Yuan, Xin Yao, Li Fan, Yilin Qi, Kailin Chen, Dongliang Guo, Zhiying Gan, Xiaolong Sun, Yaxuan Dai, Xueling Wu, Guohao Huo, Qing
- 机构：Beijing Union Univ;Chinese Acad Sci;Sci Res Inst Beijing Tongrentang Co Ltd;Beijing Union Univ
- 来源：OPEN CHEMISTRY 2023
- 关键词：arsenic speciation Lonicera japonica dimethyl arsenate acid synchrotron X-ray fluorescence spectroscopy correlation analysis
- 3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice被引量：0收藏
- 作者：Yuan, Jiaqi He, Mengjie Dai, Xueling Huo, Qing Chang, Ping Zhang, Jing Wang, Shuo Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF NEUROPHYSIOLOGY 2023
- 关键词：Alzheimer's disease apoptosis CREB/BDNF signal pathway 3,6'-disinapoyl sucrose Morris water maze
- Cu(II) promoting amyloid beta peptide sedimentation involved in histidine residues in a non-beta aggregate way被引量：0收藏
- 作者：Jiang, Z-F. Huang, H-C. Dai, X-L.
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：EUROPEAN JOURNAL OF NEUROLOGY 2009
- Effects of Tanshinone IIA on Cognitive Impairment in Alzheimer's Disease Rats Via Oxidative Stress, Inflammatory Responses and Apoptosis被引量：0收藏
- 作者：Ren, Wujiang Li, Xiaoxiao Wang, Tingqiao Liu, Yanxia Dai, Xueling Huo, Qing Wang, Shuo Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ;Binzhou Med Univ
- 来源：PHARMACOGNOSY MAGAZINE 2024
- 关键词：Tanshinone IIA cognitive impairment oxidative stress inflammation Alzheimer's disease
- Research Progress in the Analysis of Chemical Forms of Mercury in Traditional Chinese Medicine被引量：0收藏
- 作者：Peng, Congnan Kang, Liping Yuan, Xin Qiao, Jiaqi Fan, Yilin Yao, Li Qi, Kailin Sun, Yaxuan Dai, Xueling Zhang, Yuan Huo, Qing
- 机构：Beijing Union Univ;China Acad Chinese Med Sci
- 来源：PROCESSES 2023
- 关键词：analysis of chemical state mercury research progress traditional Chinese medicine
- Effects of Varied Forms of Arsenic Stress on Seedling Growth and Arsenic Distribution in Honeysuckle Plants被引量：0收藏
- 作者：Yuan, Xin Zhou, Juntong Peng, Congnan Qiao, Jiaqi Xia, Shengqi Fan, Yilin Yao, Li Qi, Kailin Chen, Dongliang Guo, Zhiying Gan, Xiaolong Sun, Yaxuan Dai, Xueling Lv, Liangyu Ji, Yizhi Huo, Qing
- 机构：Beijing Union Univ;Chinese Acad Sci;Donghua Univ
- 来源：PROCESSES 2023
- 关键词：arsenic stress honeysuckle micro X-ray fluorescence physiological indicators
- Weakened neurotoxicity and aggregate properties with a histidine to arginine substitution in a mutant amyloid beta peptide被引量：0收藏
- 作者：Dai, X-L. Huang, H-C. Jiang, Z-F.
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：EUROPEAN JOURNAL OF NEUROLOGY 2009
- Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice被引量：0收藏
- 作者：Sun, Ya-Xuan Liu, Ting Dai, Xue-Ling Li, Ya-Bo Li, Yu-Yao Zhang, Hua An, Li-Zhe
- 机构：Beijing Union Univ;Chinese Acad Sci;Shihezi Univ;Lanzhou Univ
- 来源：JOURNAL OF CHEMISTRY 2014
