文献类型：期刊文献

英文题名：Effects of Tanshinone IIA on Cognitive Impairment in Alzheimer's Disease Rats Via Oxidative Stress, Inflammatory Responses and Apoptosis

作者：Ren, Wujiang[1];Li, Xiaoxiao[1];Wang, Tingqiao[1];Liu, Yanxia[1];Dai, Xueling[1];Huo, Qing[1];Wang, Shuo[2];Zheng, Qiusheng[3];Sun, Yaxuan[1]

第一作者：Ren, Wujiang

通讯作者：Sun, YX[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Nankai Univ, Dept Food Sci, Sch Med, Tianjin, Peoples R China;[3]Binzhou Med Univ, Sch Chinese Med Integrated Western Med, Yantai, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2024

外文期刊名：PHARMACOGNOSY MAGAZINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001224057400001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (11975048); Beijing Natural Science Foundation (6164030); Beijing Key Laboratory of Bioactive Substances and Functional Foods Research Project, the Academic Research Projects of Beijing Union University (ZK80202102); and Education Reform Project of Beijing Union University (JY2023Y008).

语种：英文

外文关键词：Tanshinone IIA; cognitive impairment; oxidative stress; inflammation; Alzheimer's disease

摘要：Background The rationale for the pathogenesis of Alzheimer's disease (AD) is the production of amyloid-beta (A beta) and its resultant toxic effects.Purpose In this work, rats with AD were used as models to assess the modulatory effects of tanshinone IIA (tan IIA) in alleviating cognitive impairment, oxidative damage, inflammation and apoptosis.Materials and Methods: A beta 1-42 was injected bilaterally in the hippocampus to establish an AD rat model. The effects of tan II A on the learning and memory capacities of AD rats were detected by ethological experiments. Tan IIA's anti-inflammatory and antioxidant capacities were examined in this study using biochemical and immunohistochemical methods on rat hippocampus tissues.Results The experimental data showed that the cognitive ability of rats could be significantly improved by tan IIA. Furthermore, fewer injured neuron apoptosis was demonstrated in the tan IIA rats than in the AD group. More importantly, on the one hand, we discovered that the tan IIA group had considerably lower levels of interleukin 1 beta, tumour necrosis factor-alpha and inducible nitric oxide synthase. On the other hand, tan IIA was discovered to prevent oxidative stress by raising glutathione and superoxide dismutase activity and lowering malondialdehyde, protein carbonyl and 8-hydroxy-2 '-deoxyguanosine levels.Conclusion Tan IIA can alleviate cognitive impairment and neuronal cell damage by inhibiting oxidative stress and inflammatory responses during AD.