文献类型：期刊文献

英文题名：Morinda officinalis oligosaccharides alleviated mice chronic unpredictable mild stress induced sexual dysfunction

作者：Wang, Tingqiao[1];Liu, Zixuan[1];He, Mengjie[1];Wu, You[1];Zuo, Zeping[2];Li, Hongkai[2];Zhao, Zhiwei[2];Lv, Liangyu[3];Dai, Xueling[1];Zhang, Chaohua[2];Sun, Yaxuan[1]

第一作者：Wang, Tingqiao

通讯作者：Sun, YX[1]

机构：[1]Beijing Union Univ, Sch Biol Chem Engn, Beijing 100023, Peoples R China;[2]Beijing Tongrentang Grp, Beijing 100075, Peoples R China;[3]Rutgers State Univ, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New York, NJ 08855 USA

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Sch Biol Chem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2025

卷号：13

期号：4

外文期刊名：SEXUAL MEDICINE

收录：;Scopus(收录号：2-s2.0-105016559179);WOS:【SCI-EXPANDED(收录号:WOS:001574540900001)】；

基金：This project is supported by the Comparative study of accreditation systems for drug testing laboratories (2023MK215) and the phase I clinical and antidepressant effect mechanism study of Morinda officinalis oligosaccharides capsule (2014ZX09301307-014).

语种：英文

外文关键词：Morinda officinalis oligosaccharides; cums; depression; sexual dysfunction; traditional Chinese medicine

摘要：Background Chronic stress can not only lead to depression-like behavior but also sexual dysfunction. Morinda officinalis oligosaccharides (MOO) is a formula of traditional Chinese medicine commonly used in invigorating the kidney and strengthening Yang, and relieving depression.Aim This study was designed to explore the effects and mechanisms of MOO in treating chronic stress-induced depression as well as sexual dysfunction.Methods The sucrose preference test, forced swimming test (FST) and novelty-suppressed feeding test (NSFT) were carried out to evaluate the depression status. Sexual behavior was tested on all mice, then the extent of damage to the testicles and epididymis was assessed by H&E staining; Serum sex hormone and neurotransmitters were assessed in the plasma by Enzyme-Linked Immunosorbent Assay. The testicular tissues were applied with the kit for the detection of antioxidant-related indexes and reproductive-related hormones.Outcomes The study evaluates the effects of MOO on depression-like behaviors and sexual function levels in CUMS-induced mice by analyzing the behavioral tests, histopathological staining of testis and epididymis, sex hormones, antioxidant capacity, neurotransmitter levels, and sexual behavior abilities of mice in each group.Results CUMS led to mice depression and plasma neurotransmitter levels decreased. Accompanying sexual dysfunction in depressed mice was also manifested in many aspects. Compared with the control group, the capture latency and mount latency of male mice in model group were significantly prolonged. HE showed that testicular and epididymal tissues of mice in the CUMS group were severely vacuolated. Testicular marker enzymes, antioxidant indexes and sex hormones were disorganized. The sperm concentration and viability in the epididymis of the mice in model group were significantly reduced. It was suggested that MOO could improve the damage caused by CUMS, and improve the sperm quality of the model mice.Clinical Translation MOO are promising to be translated into a potential therapeutic drug for clinically improving chronic stress-related depression and sexual dysfunction.Strengths and Limitations Multi-dimensional verification confirms that MOO can effectively alleviate depressive states and sexual dysfunction in CUMS-induced mice. Future studies should explore the in-depth mechanisms underlying its antidepressant and anti-sexual dysfunction effects based on relevant signaling pathways.Conclusion These results suggest that MOO can regulate sexual dysfunction and play a protective role in neurodevelopment during CUMS by regulating sex hormones.