成果/Result
- High Production of 3-Hydroxypropionic Acid in Klebsiella pneumoniae by Systematic Optimization of Glycerol Metabolism被引量：73收藏
- 作者：Li, Ying Wang, Xi Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：SCIENTIFIC REPORTS 2016
- Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies被引量：31收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：MICROBIOLOGY SPECTRUM 2023
- 关键词：berberine efflux pump inhibitor salt bridge conformational transition
- Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis被引量：30收藏
- 作者：Wang, Jingxuan Zhao, Peng Li, Ying Xu, Lida Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：MICROBIAL CELL FACTORIES 2018
- 关键词：CRISPR interference Klebsiella pneumoniae 3-Hydroxypropionic acid Lactic acid Lactate dehydrogenase
- Evaluation of berberine as a natural fungicide: biodegradation and antimicrobial mechanism被引量：29收藏
- 作者：Li, Ying Yin, Yi-Ming Wang, Xin-Yue Wu, Hao Ge, Xi-Zhen
- 机构：Beijing Union Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2018
- 关键词：Berberine antimicrobial mechanism glucan bacterial diversity degradation
- Multipath effects of berberine on peach Brown rot fungus Monilinia fructicola被引量：28收藏
- 作者：Pei, Qinghui Li, Ying Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：CROP PROTECTION 2019
- 关键词：Monilinia fructicola Peach brown rot Berberine Transcriptomic analysis
- Hormesis Effect of Berberine against Klebsiella pneumoniae Is Mediated by Up-Regulation of the Efflux Pump KmrA被引量：23收藏
- 作者：Li, Ying Wen, Honglin Ge, Xizhen
- 机构：Beijing Union Univ;Capital Med Univ
- 来源：JOURNAL OF NATURAL PRODUCTS 2021
- Analysis of AcrB in Klebsiella pneumoniae reveals natural variants promoting enhanced multidrug resistance被引量：15收藏
- 作者：Li, Ying Cross, Trevor S. Dorr, Tobias
- 机构：Cornell Univ;Beijing Union Univ;Cornell Univ
- 来源：RESEARCH IN MICROBIOLOGY 2022
- 关键词：AcrAB Efflux pump Resistance-nodulation-cell division Antibiotic resistance
- Lignocellulose mulch increases the economic benefit of Chinese chestnut by suppressing weed and ameliorating soil properties被引量：12收藏
- 作者：Tian, Geran Li, Ying
- 机构：Univ Int Business & Econ;Beijing Union Univ
- 来源：SCIENTIA HORTICULTURAE 2022
- 关键词：Chinese chestnut Lignocellulose mulch Weed suppression Soil diversity Economic benefit
- Isolation and characterization of a novel bacterium Pseudomonas aeruginosa for biofertilizer production from kitchen waste oil被引量：9收藏
- 作者：Li, Ying Cui, Ting Wang, Yaxin Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：RSC ADVANCES 2018
- 关键词：Agricultural robots - Bacteria - Biodegradation - Cultivation - Degradation - Fatty acids - Fertilizers - Gas chromatography - Kitchens - Mass spectrometry - Petroleum industry - Probiotics
- Saprophytic Bacillus Accelerates the Release of Effective Components in Agarwood by Degrading Cellulose被引量：8收藏
- 作者：Yang, Huizhen He, Runying Cui, Yao Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：MOLECULES 2022
- 关键词：saprophytic Bacillus Agarwood cellulose effective components
- Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity被引量：7收藏
- 作者：Li, Ying Wei, Jinqing Yang, Huizhen Dai, Jing Ge, Xizhen
- 机构：Beijing Union Univ;Beijing Aerosp Petrochem EC & EP Technol Co Ltd
- 来源：PLOS ONE 2021
- Co-production of 1,3-Propanediol and 2,3-Butanediol from Waste Lard by Co-cultivation of Pseudomonas alcaligenes and Klebsiella pneumoniae被引量：7收藏
- 作者：Li, Ying Zhu, Siyu Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：CURRENT MICROBIOLOGY 2019
- Discovering interrelated natural mutations of efflux pump KmrA from Klebsiella pneumoniae that confer increased multidrug resistance被引量：7收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：PROTEIN SCIENCE 2022
- 关键词：efflux pump Klebsiella pneumoniae major facilitator superfamily molecular dynamics
- Molecular Dynamics Investigation of MFS Efflux Pump MdfA Reveals an Intermediate State between Its Inward and Outward Conformations被引量：7收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
- 关键词：major facilitator superfamily efflux pump conformational transition intermediate state molecular dynamics
- Expression of the TetA gene encoding TetA efflux protein in E. coli contributes to its increased bacterial resistance toward berberine被引量：6收藏
- 作者：Li, Ying Cao, Zhe-Tong Wang, Xin-Yue Ge, Xi-Zhen
- 机构：Beijing Union Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2018
- 关键词：TetA efflux protein berberine bacterial resistance tetracycline EC50
- Identification of a novel hydrolase encoded by hy-1 from Bacillus amyloliquefaciens for bioremediation of carbendazim contaminated soil and food被引量：6收藏
- 作者：Li, Ying Chi, Miaomiao Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING 2019
- 关键词：carbendazim bioremediation antifungal and antibacterial pesticide hydrolase soil food pesticide contamination
- Natural compound berberine inhibits apple ring rot fungus Botryosphaeria dothidea被引量：6收藏
- 作者：Li, Pengyu Liu, Jinrong Li, Ying Yang, Tao Ge, Xizhen Tian, Pingfang
- 机构：Beijing Union Univ;Beijing Univ Chem Technol
- 来源：INTERNATIONAL JOURNAL OF PEST MANAGEMENT 0
- 关键词：Apple ring rot berberine Botryosphaeria dothidea enzyme activity inhibition rate
- Enhanced internal ionic interaction of MFS efflux pump MdfA contributes to its elevated antibiotic export被引量：5收藏
- 作者：Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 0
- Regulatory mechanism of fermented wheat germ on lipid metabolism in hyperlipidemia rats via activation of AMPK pathway被引量：5收藏
- 作者：Mi, Shengquan Gu, Junxia Cao, Xuelian Li, Yi Xu, Qile Chen, Wen Zhang, Yanzhen
- 机构：Beijing Union Univ;Beijing Key Lab Bioact Subst & Funct Foods
- 来源：FOOD SCIENCE AND TECHNOLOGY 2022
- 关键词：fermented wheat germ lipid metabolism hyperlipidemia AMPK
- Development of a Red recombinase system and antisense RNA technology in Klebsiella pneumoniae for the production of chemicals被引量：5收藏
- 作者：Li, Ying Li, Sha Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：RSC ADVANCES 2016
- 关键词：Acetic acid - Escherichia coli - Genes - Genetic engineering - Glycerol - Lactic acid - Metabolism - pH
- Production of 1,3-propanediol from glycerol using a new isolate Klebsiella sp AA405 carrying low levels of virulence factors被引量：5收藏
- 作者：Li, Ying Ge, Xi-Zhen Tian, Ping-Fang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 2017
- 关键词：Klebsiella pneumoniae virulence factor endotoxin 1,3-propanediol 2,3-butanediol
- Glycerol promotes biomass accumulation of Klebsiella pneumoniae by activating dha regulon被引量：3收藏
- 作者：Li, Ying He, Runying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：PROCESS BIOCHEMISTRY 2022
- 关键词：Klebsiella pneumoniae Glycerol Dha regulon Biomass accumulation Transcriptome analysis
- Opposite motion of the Central Helices of efflux pump KmrA is important for its export efficiency被引量：3收藏
- 作者：Li, Ying Wen, Honglin Ge, Xizhen
- 机构：Beijing Union Univ;Capital Med Univ
- 来源：MICROBIAL PATHOGENESIS 2022
- 关键词：Efflux pump Major facilitator superfamily Opposite motion Antibiotic resistance
- Identification of the Major Facilitator Superfamily Efflux Pump KpsrMFS in Klebsiella pneumoniae That Is Down-Regulated in the Presence of Multi-Stress Factors被引量：3收藏
- 作者：He, Wei Jiang, Minzhi Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
- 关键词：efflux pump antibiotic resistance Klebsiella pneumoniae down-regulated reactive oxygen species
- Tetrahydroisoquinoline N-methyltransferase from Methylotenera Is an Essential Enzyme for the Biodegradation of Berberine in Soil Water被引量：1收藏
- 作者：He, Runying Cui, Yao Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：MOLECULES 2022
- 关键词：berberine soil water Methylotenera tetrahydroisoquinoline N-methyltransferase biodegradability
- Metabolic Checkpoint Aldehyde Dehydrogenases Are Important for Diverting beta-Oxidation into 1-Butanol Biosynthesis from Kitchen Waste Oil in Pseudomonas aeruginosa被引量：1收藏
- 作者：Li, Ying Liu, Zheng Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2021
- 关键词：1-Butanol Kitchen waste oil Forward β -oxidation Binding energy Checkpoint
- Berberine Degradation Characteristics and its Degradation Pathway by a Newly Isolated Berberine-Utilizing Agrobacterium被引量：1收藏
- 作者：Cui, Yao He, Wei Li, Ying Ge, Xizhen
- 机构：Beijing Union Univ
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2024
- 关键词：Berberine Agrobacterium sp. Whole genome sequencing Degradation Degradation pathway
- Dual-functional berberine-magnolol co-assembled nanoparticles inhibit Fusarium graminearum growth and mycotoxin production被引量：1收藏
- 作者：Li, Chenguo He, Wei Cui, Yao Wu, Shimin Song, Qing'ao Li, Ying Guo, Jimin Ge, Xizhen Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ;Beijing Univ Chem Technol;Beijing Univ Chem Technol
- 来源：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2025
- 关键词：Magnolol Berberine Co-assembly Fusarium graminearum Deoxynivalenol
- Decoupling adhesion from carbon metabolism via FimA deletion in Klebsiella pneumoniae type 1 pili被引量：0收藏
- 作者：Chen, Liuni Wu, Shimin Li, Ying Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2026
- 关键词：Klebsiella pneumoniae Type 1 pilus Adhesion
- Metabolic Engineering of Escherichia coli for De Novo Biosynthesis of the Platform Chemical Pelletierine被引量：0收藏
- 作者：Li, Wei Zhao, Peng Li, Ying Wu, Shimin Tian, Pingfang
- 机构：Beijing Univ Chem Technol;Beijing Univ Agr;Beijing Union Univ
- 来源：ACS SUSTAINABLE CHEMISTRY & ENGINEERING 2025
- 关键词：huperzine A pelletierine Alzheimer'sdisease Escherichia coli metabolic engineering
