成果/Result
- A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide被引量：104收藏
- 作者：Liang, Shuang Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
- 关键词：chitin chitosan chitooligosaccharide (COS) COS preparation COS analysis COS biological activity
- Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-beta(1-42)-induced rat model of Alzheimer's disease被引量：101收藏
- 作者：Jia, Shiliang Lu, Zheng Gao, Zhaolan An, Jun Wu, Xueling Li, Xiaoxiao Dai, Xueling Zheng, Qiusheng Sun, Yaxuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2016
- 关键词：Alzheimer's disease Amyloid-beta(1-42) Chitosan oligosaccharides Oxidative stress Neuroinflammation
- Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties被引量：86收藏
- 作者：Sun, Ya-Xuan Tang, Yue Wu, Ai-Li Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Wang, Zhi-Bin
- 机构：Beijing Inst Drug Control;Beijing Union Univ;Chinese Acad Sci;Chinese Acad Med Sci;Chinese Acad Med Sci
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2010
- 关键词：liquiritin mice focal cerebral ischemia reperfusion antioxidant anti-apoptosis
- Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid beta-Mediated Neurotoxicity被引量：45收藏
- 作者：Dai, Xueling Hou, Wanqi Sun, Yaxuan Gao, Zhaolan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Capital Normal Univ;Peking Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015
- 关键词：Alzheimer's disease amyloid- peptide chitosan oligosaccharides aggregation neurotoxicity
- Protective Effects of Curcumin on Amyloid-beta-Induced Neuronal Oxidative Damage被引量：42收藏
- 作者：Huang, Han-Chang Chang, Ping Dai, Xue-Ling Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Beijing Univ Chem Technol;Beijing Union Univ
- 来源：NEUROCHEMICAL RESEARCH 2012
- 关键词：Alzheimer's disease (AD) Amyloid-beta (A beta) Curcumin Molecular interaction Oxidative damage
- Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric beta-amyloid 1-42-induced neurotoxicity被引量：41收藏
- 作者：Dai, Xueling Chang, Ping Zhu, Qingzhu Liu, Wenjuan Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Beijing Union Univ;Peking Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2013
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides Neurotoxicity
- Copper Enhances Amyloid-beta Peptide Neurotoxicity and non beta-Aggregation: A Series of Experiments Conducted upon Copper-Bound and Copper-Free Amyloid-beta Peptide被引量：40收藏
- 作者：Dai, Xueling Sun, Yaxuan Gao, Zhaolan Jiang, Zhaofeng
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：JOURNAL OF MOLECULAR NEUROSCIENCE 2010
- 关键词：Alzheimer's disease Amyloid-beta peptide beta aggregation Neurotoxicity
- Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-beta(1-42) oligomers injected into the hippocampus被引量：37收藏
- 作者：Jia, Shi-Liang Wu, Xue-Ling Li, Xiao-Xiao Dai, Xue-Ling Gao, Zhao-Lan Lu, Zheng Zheng, Qiu-Sheng Sun, Ya-Xuan
- 机构：Beijing Union Univ;Binzhou Med Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2016
- 关键词：Liquiritin alzheimer's disease amyloid-beta(1-42) oxidative stress apoptosis
- Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia被引量：32收藏
- 作者：Sun, Ya-Xuan Liu, Ting Dai, Xue-Ling Zheng, Qiu-Sheng Hui, Bo-Di Jiang, Zhao-Feng
- 机构：Beijing Union Univ;Shihezi Univ
- 来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2014
- 关键词：oxidative stress lutein neuroprotection antioxidant transient cerebral ischemia
- Effect of Oat Barley Powder on Glucose and Lipid Metabolism and Oxidative Stress in Type II Diabetic Mice被引量：30收藏
- 作者：Gao, Xiaohan Wang, LiguO Zhang, Shiwen Dai, Xueling Zhang, Jing Wei, Tao Mi, Shengquan Sun, Yaxuan
- 机构： Beijing Key Laboratory of Bioactive Substances and Functional Foods; Guzhen Zhangjiakou Food Co.Ltd.; Beijing Daxing Xinghua High School
- 来源：Journal of Chinese Institute of Food Science and Technology 2022
- 关键词：Blood - Glucose - Insulin - Lactic acid - Mammals - Oxidative stress - Peptides - Superoxide dismutase
- The immunometabolic reprogramming of microglia in Alzheimer's disease被引量：23收藏
- 作者：Chen, Hongli Guo, Zichen Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROCHEMISTRY INTERNATIONAL 2023
- 关键词：Microglia Immunometabolism Reprogramming Neuroinflammation Alzheimer's disease
- Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway被引量：23收藏
- 作者：Zhang, Xiaoxia Liang, Shuang Gao, Xiaohan Huang, Hanchang Lao, Fengxue Dai, Xueling
- 机构：Beijing Union Univ
- 来源：NEUROTOXICITY RESEARCH 2021
- 关键词：Chitosan oligosaccharide Oxidative stress Cell apoptosis Nrf2 MAPKs
- Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease被引量：22收藏
- 作者：Zheng, Bo-Wen Yang, Li Dai, Xue-Ling Jiang, Zhao-Feng Huang, Han-Chang
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROLOGICAL RESEARCH 2016
- 关键词：Alzheimer disease APP processing Hippocampal synapses O-GlcNAcylation Tau phosphorylation
- Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-beta(1-42) Induced Alzherimer's Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry被引量：14收藏
- 作者：Liang, Shuang Wang, Zijian Yuan, Jiaqi Zhang, Jing Dai, Xueling Qin, Fei Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Union Univ;Binzhou Med Univ
- 来源：MOLECULES 2019
- 关键词：Tanshinone IIA Alzheimer's disease UHPLC-Q-Exactive Qrbitrap mass spectrometry metabolic pathway hippocampus rat model Morris water maze test passive avoidance test
- Chitooligosaccharide ameliorates cognitive deficits and neuroinflammation in APP/PS1 mice associated with the regulation of Nrf2/NF-κB axis被引量：14收藏
- 作者：Cai, Mingyang Zhang, Xiaoxia Gao, Xiaohan Huo, Qing Sun, Yaxuan Dai, Xueling
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Chitooligosaccharide Cognitive deficits Neuroinflammation Nrf2 NF-kappa B NLRP3 inflammasome
- The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Li, Xiaoxiao Gao, Zhaolan Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Union Univ
- 来源：NEUROSCIENCE LETTERS 2018
- 关键词：Alzheimer's disease beta-Amyloid peptide Chitosan oligosaccharides beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1)
- Protective effects of fisetin in an A beta(1-42)-induced rat model of Alzheimer's disease被引量：12收藏
- 作者：Wang, Yunting Wu, Xueling Ren, Wujiang Liu, Yanxia Dai, Xueling Wang, Shuo Huo, Qing Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：FOLIA NEUROPATHOLOGICA 2023
- 关键词：Alzheimer's disease A beta(1-42) fisetin protective effects mechanism
- A beta-40 Y10F Increases beta fibrils Formation but Attenuates the Neurotoxicity of Amyloid-beta Peptide被引量：12收藏
- 作者：Dai, Xueling Chang, Ping Liu, Wenjuan Xu, Ke Sun, Yaxuan Zhu, Shigong Jiang, Zhaofeng
- 机构：Peking Univ;Beijing Union Univ;Capital Normal Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2012
- 关键词：Alzheimer's disease amyloid-beta peptide beta fibrils neurotoxicity
- 阿尔茨海默病实验动物模型研究进展被引量：11收藏
- 作者：宋春未 戴雪伶 姜招峰
- 机构：北京联合大学生物活性物质与功能食品北京市重点实验室;北京联合大学功能食品科学技术研究院
- 来源：《生物学杂志》 2013
- 关键词：阿尔茨海默病 动物模型 β-淀粉样蛋白 转基因动物
- 摘要：阿尔茨海默病(Alzheimer's Disease,AD)是一种神经退行性疾病,临床表现为认知功能障碍、行为异常及日常生活能力下降;病理学改变包括神经元变性、丢失引起的脑萎缩,神经细胞外存在大量老年斑(senile p...
- 基于淀粉样蛋白级联假说的阿尔茨海默症防治研究进展被引量：10收藏
- 作者：戴雪伶 姜招峰
- 机构：北京联合大学生物活性物质与功能食品北京市重点实验室
- 来源：《生物学杂志》 2014
- 关键词：阿尔茨海默症 淀粉样蛋白级联假说 β-淀粉样蛋白
- 摘要：阿尔茨海默症(Alzheimer's Disease,AD)是一种中枢神经系统退行性病变,目前发病机制不清。淀粉样蛋白级联假说是有关AD发病机制的主流学说,认为脑内过量产生的β-淀粉样蛋白(β-amyloid pepti...
- Rapid Identification of 3,6 '-Disinapoyl Sucrose Metabolites in Alzheimer's Disease Model Mice Using UHPLC-Orbitrap Mass Spectrometry被引量：10收藏
- 作者：Yuan, Jiaqi Wang, Han Wang, Yunting Wang, Zijian Huo, Qing Dai, Xueling Zhang, Jiayu Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Binzhou Med Univ
- 来源：MOLECULES 2022
- 关键词：Alzheimer's disease 3,6 '-disinapoyl sucrose UHPLC-Orbitrap mass spectrometry metabolites metabolic pathway
- 黑果枸杞提取物活性的研究进展被引量：10收藏
- 作者：武雪玲 李筱筱 戴雪伶 孙雅煊
- 机构：北京联合大学应用文理学院;北京联合大学功能食品科学技术研究院
- 来源：《生命的化学》 2017
- 关键词：黑果枸杞 提取物 生物活性
- 摘要：黑果枸杞是一种具有良好保健功效的药食两用植物,其富含丰富的营养物质,具有多种生物活性。本文综述了黑果枸杞中花青素、多糖和甜菜碱等活性成分的性质及其保健功效的研究进展,为黑果枸杞的深入研究及进一步的开发应用提供科学依据。
- 生物活性物质壳寡糖对阿尔茨海默病防治作用研究进展被引量：9收藏
- 作者：张姣 戴雪伶 姜招峰
- 机构：北京联合大学生物活性物质与功能食品北京市重点实验室功能食品科学技术研究院
- 来源：《食品科学》 2013
- 关键词：壳寡糖 阿尔茨海默病 神经保护
- 摘要：阿尔茨海默病是一种以神经元细胞大量凋亡,神经元细胞内神经纤维缠结以及神经元细胞外老年斑形成为主要病理学特征的中枢神经退行性疾病。壳寡糖,又名为β-1,4-寡聚-葡萄糖胺,是唯一带正电的天然碱性多糖,具有多种生物活性。壳寡...
- Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of beta-amyloid peptide被引量：9收藏
- 作者：Zhang, Jian-Xiang Lai, Yi-Hui Mi, Pan-Ying Dai, Xue-Ling Zhang, Ran Zhang, Zhan-Jun Zhang, Shu-Juan Zhang, Xi-Wen Zhang, Xi-Yan Yang, Bing-Yu Cui, Dong-Mei Zhang, Chen Zhao, Chang-Qi Dou, Fei
- 机构：Beijing Normal Univ;Beijing Union Univ;Beijing Normal Univ;Peking Univ;161 Middle Sch
- 来源：ALZHEIMERS RESEARCH & THERAPY 2019
- 关键词：Alzheimer's disease beta-Amyloid Oligomers Globulomers Flavonoid
- 抑郁症动物模型的建立及评价方法研究进展被引量：7收藏
- 作者：刘子轩 霍清 孙雅煊 戴雪伶 李昕
- 机构：北京联合大学生物化学工程学院
- 来源：《中国实验动物学报》 2025
- 关键词：抑郁症 动物模型 发病机制
- 摘要：抑郁症是一种常见的慢性精神疾病,抑郁症动物模型被广泛应用于抑郁症发病机制的研究和抗抑郁新药的研发,其模拟人类抑郁症状的同一性和可靠性会直接影响研究结果。然而,目前还尚未发现与人类抑郁症发病完全契合的动物模型,阻碍了对抑郁...
- 益生菌复合制剂对头孢曲松钠作用小鼠的抗氧化指标、细胞因子及肠道菌群的影响被引量：6收藏
- 作者：郭子晨 刘倩 王韵婷 王涵 赵江燕 赵雅欣 孙雅煊 戴雪伶
- 机构：北京联合大学生物化学工程学院;北京联合大学应用文理学院保健食品检测中心
- 来源：《食品工业科技》 2022
- 关键词：头孢曲松钠 长双歧杆菌BB536 乳双歧杆菌HN019 益生菌复合制剂 肠道菌群
- 摘要：目的:探究长双歧杆菌BB536和乳双歧杆菌HN019组成的益生菌复合制剂对头孢曲松钠引起的肠道菌群失调的改善效果。方法:头孢曲松钠(2 mg/g)连续灌胃小鼠5 d,构建肠道菌群失调模型小鼠,然后随机分为模型组,益生菌复...
- 壳寡糖减轻过氧化氢诱导的SK-N-SH细胞氧化损伤机制研究被引量：6收藏
- 作者：张晓霞 李筱筱 孙雅煊 戴雪伶
- 机构：北京联合大学生物化学工程学院
- 来源：《食品与发酵工业》 2021
- 关键词：壳寡糖 H2 O2 细胞凋亡 Bcl-2 Bax Nrf2 HO-1
- 摘要：为探讨壳寡糖(chitosan oligosaccharide,COS)对H_(2)O_(2)诱导的人神经母细胞瘤SK-N-SH细胞损伤的保护作用及其机制,利用H_(2)O_(2)建立体外氧化损伤模型,MTT法检测细胞存...
- 3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice被引量：5收藏
- 作者：Yuan, Jiaqi He, Mengjie Dai, Xueling Huo, Qing Chang, Ping Zhang, Jing Wang, Shuo Sun, Yaxuan
- 机构：Beijing Union Univ;Nankai Univ
- 来源：JOURNAL OF NEUROPHYSIOLOGY 2023
- 关键词：Alzheimer's disease apoptosis CREB/BDNF signal pathway 3,6'-disinapoyl sucrose Morris water maze
- Effects of Varied Forms of Arsenic Stress on Seedling Growth and Arsenic Distribution in Honeysuckle Plants被引量：4收藏
- 作者：Yuan, Xin Zhou, Juntong Peng, Congnan Qiao, Jiaqi Xia, Shengqi Fan, Yilin Yao, Li Qi, Kailin Chen, Dongliang Guo, Zhiying Gan, Xiaolong Sun, Yaxuan Dai, Xueling Lv, Liangyu Ji, Yizhi Huo, Qing
- 机构：Beijing Union Univ;Chinese Acad Sci;Donghua Univ
- 来源：PROCESSES 2023
- 关键词：arsenic stress honeysuckle micro X-ray fluorescence physiological indicators
- Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice被引量：4收藏
- 作者：He, Mengjie Hu, Mengying Wang, Tingqiao Zuo, Zeping Li, Hongkai Zhao, Zhiwei Hao, Yunwen Dai, Xueling Wang, Jianfang Sun, Yaxuan
- 机构：Beijing Union Univ;Beijing Univ Chinese Med;Beijing Tongrentang Co Ltd;Univ British Columbia;Beijing Univ Chinese Med
- 来源：FRONTIERS IN NEUROSCIENCE 2025
- 关键词：
Morinda officinalis oligosaccharides depression CUMS BDNF/TrkB/CREB pathway gut microbiota sexual dysfunction
