文献类型：期刊文献

英文题名：alpha-Tocospiro C, a novel cytotoxic alpha-tocopheroid from Cirsium setosum

作者：Yuan, Zhenzhen[1];Duan, Hongmei[2];Xu, Yingying[1];Wang, Ali[1];Gan, Lishe[3];Li, Jinjie[1];Liu, Mingtao[1];Shang, Xiaoya[1]

第一作者：Yuan, Zhenzhen

通讯作者：Liu, MT[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Univ Chinese Med, Sch Nursing, Beijing 100102, Peoples R China;[3]Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd Haidian Dist, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2014

卷号：8

起止页码：116-120

外文期刊名：PHYTOCHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000335743300025)】；

基金：The work was supported by the National Natural Science Foundation of China (Grant No. 31171669); and Beijing Natural Sciences Foundation (Grant No. 7142028).

语种：英文

外文关键词：Cirsium setosum; alpha-Tocospiro C; Absolute configuration; Cytotoxic activities

摘要：alpha-Tocospiro C (1), the first example of nor-alpha-tocopheroid possessing unusual 7,8-dimethyl-1-oxaspiro[ 4.4] non-7-ene-6,9-dione carbon skeleton, was isolated and characterized from Cirsium setosum. Its structure and absolute configuration were determined by extensive spectroscopic methods, especially 2D NMR and ECD data analysis. The biosynthetic pathway was postulated. alpha-Tocospiro C (1) exhibited significant selective cytotoxic activities against human colon cancer (HCT8) cells, with IC50 values of 0.03 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.