文献类型：会议论文

中文题名：Amyloid-β peptide induces mitochondrial oxidative damage in alzheimer's disease

作者：黄汉昌[1];徐峰[1];姜招峰[1];

第一作者：黄汉昌

机构：[1]北京联合大学功能食品科学技术研究院;

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院功能食品科学技术研究院

会议论文集：生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会摘要集

会议日期：20120824

会议地点：中国四川成都

主办单位：中国生物化学与分子生物学会(The Chinese Society of Biochemistry and Molecular Biology)

语种：中文

摘要：<正>Background:Alzheimer''''s disease(AD) is one of the most common forms of neurodegen-erative disease.Amyloid-β(Aβ) is considered as a centre molecule and plays a key role in AD pathological development.The accumulating aggregation of Aβin neuritic plaques in-curs neuronal oxidative damage,neurofibrillary tangles,and loss of hippocampal neurite,synapse and neuron. The elevated oxidative stress is thought to be links the age-related neurodegeneration.The elevated oxidative stress is also thought to be a key even on the Aβ-induced neurotoxicity.However,the pathways of Aβ-induced oxidative damages are under controversies.