文献类型：期刊文献

英文题名：Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice

作者：Sun, Ya-Xuan[1,2];Liu, Ting[3];Dai, Xue-Ling[1];Li, Ya-Bo[4];Li, Yu-Yao[4];Zhang, Hua[4];An, Li-Zhe[4]

第一作者：Sun, Ya-Xuan;孙雅煊

通讯作者：An, LZ[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Chinese Acad Sci, Cold & Arid Reg Environm & Engn Res Inst, Lanzhou 730000, Peoples R China;[3]Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China;[4]Lanzhou Univ, Sch Life Sci, Minist Educ, Key Lab Arid & Grassland Agroecol, Lanzhou 730000, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Lanzhou Univ, Sch Life Sci, Minist Educ, Key Lab Arid & Grassland Agroecol, Lanzhou 730000, Peoples R China.

年份：2014

卷号：2014

外文期刊名：JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000338541600001)】；

基金：This study was supported by the National Outstanding Youth Foundation of China (30625008), the National High Technology Research and Development Program (863 Program, 2007AA021401), National Basic Research Program of China (973, 2007CB108902), International Cooperation Program of the Ministry of Science and Technology of China (2009DFA61060), the Major Project of Cultivating New Varieties of Transgenic Organisms (2008ZX08009-003), and the National Natural Science Foundation (30900172). This work was supported by Grants the National Basic Research Program of China (973 Program 2013CB429904); the Key Program of National Nature Science Foundation of China (31230014); the Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality [PHR201107150, PHR201108422].

语种：英文

摘要：The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities.