文献类型：期刊文献

中文题名：Polysaccharide conjugate vaccine:A kind of vaccine with great development potential

作者：Jing Zhao[1];Gang Hud[4];Yi Huang[5];Yingchun Huang[3];Xin Wei[2];Jianyou Shi[1]

第一作者：Jing Zhao

机构：[1]Department of Pharmacy,Sichuan Academy of Medical Science&Sichuan Provincial People's Hospital,Personalized Drug Therapy Key Laboratory of Sichuan Province,University of Electronic Science and Technology of China,Chengdu 610072,China;[2]Chengdu Kanghua Biological Products Co.,Ltd.,Chengdu 610100,China;[3]College of Biochemical Engineering,Beijing Union University,Beijing 100023,China;[4]Galactophore Department,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China;[5]Clinical Laboratory,Sichuan Academy of Medical Sciences of Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China

第一机构：Department of Pharmacy,Sichuan Academy of Medical Science&Sichuan Provincial People's Hospital,Personalized Drug Therapy Key Laboratory of Sichuan Province,University of Electronic Science and Technology of China,Chengdu 610072,China

年份：2021

卷号：32

期号：4

起止页码：1331-1340

中文期刊名：中国化学快报：英文版

外文期刊名：Chinese Chemical Letters

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：funded by National Natural Science Foundation of China(No.82073311);Key Research Development Program of Science and Technology Department of Sichuan Provincial(No.2019YFS0514);National Natural Science Foundation of China(No.81741100);the Natural Science Foundation of Beijing,China(No.6181001);National Key Research and Development Program of China(No.2020YFC2005500);Key Research and Development Program of Science and Technology Department of Sichuan Province(No.2019YFS0514);The Major Science and Technology R&G Program of Jiangxi Province(No.20194ABC28007)。

语种：英文

中文关键词：Haemophilus influenzae type b(Hib);Streptococcus pneumoniae;Neisseria meningitides;Protein carriers;Coupling chemistry;Quality control

摘要：Diseases caused by microbial bacteria such as Haemophilus influenzae type b(Hib),Streptococcus pneumoniae and Neisseria meningitidis are still very serious disease,which has brought a lot of burden to many countries.Development of vaccine has brought hope for the prevention of such diseases.Polysaccharide conjugate vaccines have been shown to have very good effects in preventing such diseases.The polysaccharide co njugate vaccine adds the positive characteristics of protein antigens to the polysaccharide antigen,thereby improving the immunogenicity of the polysaccharide antigen,solving the problem that the polysaccharide vaccine cannot be effectively applicated in toddler or children,which greatly promoting the development of this vaccine.This review introduces the progress of polysaccharide conjugate vaccines.We introduce the typical polysaccharide conjugate vaccines currently on the market firstly,and then elucidate the protein carriers,the coupling chemistry methods and quality control that required in the preparation of polysaccharide conjugate vaccines.We can see that polysaccharide conjugate vaccine is a kind of vaccine with great development potential,which can be a sharp edge for us to prevent diseases.