文献类型：期刊文献

英文题名：New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

作者：Hou, Bolin[1];Liu, Sushi[1,2];Huo, Ruiyun[1];Li, Yueqian[1,3];Ren, Jinwei[1];Wang, Wenzhao[1];Wei, Tao[2];Jiang, Xuejun[1];Yin, Wenbing[1];Liu, Hongwei[1];Liu, Ling[1];Li, Erwei[1,3]

第一作者：Hou, Bolin

通讯作者：Liu, L[1];Li, EW[1];Li, EW[2]

机构：[1]Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[3]Chinese Acad Sci, Inst Ctr Shared Technol & Facil, Inst Microbiol, Beijing 100101, Peoples R China

第一机构：Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China;[2]corresponding author), Chinese Acad Sci, Inst Ctr Shared Technol & Facil, Inst Microbiol, Beijing 100101, Peoples R China.

年份：2021

卷号：19

期号：7

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000676293000001)】；

基金：This work was supported by the National Key R&D Program of China (2018YFC0311002), the National Natural Science Foundation of China (32022002, 21772228 and 21977113), and the Senior User Project of RV KEXUE (No. KEXUE2019GZ05) of Center for Ocean Mega-Science, Chinese Academy of Sciences.

语种：英文

外文关键词：mangrove-derived fungus; secondary metabolites; absolute configurations; bioactivity

摘要：Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A-D (4-7), together, with seven known metabolites (3 and 8-13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4 ' in 6 and C-9 in 7 were determined by [Rh-2(OCOCF3)(4)]-induced ECD spectra. Compound 1 showed moderate alpha-glucosidase inhibitory activities with IC50 values of 741.5 +/- 2.83 mu M. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 +/- 0.24 and 3.69 +/- 0.07 mu M, respectively.