文献类型：期刊文献

英文题名：Effects of Nostoc sphaeroids Kutz polysaccharide on renal fibrosis in high-fat mice

作者：Yang, Litao[1];Liu, Yinlu[1];Bi, Cuicui[1];Zhang, Bo[1]

第一作者：Yang, Litao

通讯作者：Zhang, B[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Coll Biochem Engn, Beijing, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Coll Biochem Engn, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2022

卷号：10

期号：5

起止页码：1357-1367

外文期刊名：FOOD SCIENCE & NUTRITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000770985100001)】；

基金：Hunan Yandi Bioengineering Co., Ltd.

语种：英文

外文关键词：high-fat diet; inflammation; lipid-decreasing; Nostoc sphaeroids Kutz polysaccharide; renal fibrosis

摘要：In this study, we investigated the effects of Nostoc sphaeroids Kutz polysaccharide (NSKP) on renal fibrosis in high-fat mice. ApoE(-/-) male mice were randomly divided into four groups: control (Cont) group, high-fat diet (HFD) group, HFD+0.4 g/kg BW NSKP, and HFD+0.8 g/kg BW NSKP (NSKP groups). The Cont was fed a standard diet. The HFD group was fed HFD. Every day, NSKP groups were fed HFD, as well as given 0.4 g/kg BW or 0.8 g/kg BW NSKP. After 22 weeks, the serum biochemical indices (TC, TG, LDL-C, HDL-C, GLU, BUN, and SCR) were measured. For the kidney, the histopathological sections were observed and analyzed, and inflammatory factors and markers of renal fibrosis were measured. For the NSKP groups, the serum TC, TG, LDL-C, BUN, and SCR were decreased, HDL-C significantly increased compared with the HFD group. The protein expressions of TNF-alpha, IL-1 beta and TGF-beta 1 were significantly downregulated. The alpha-SMA in renal cortex was decreased, and the mRNA expression of Col-I and Col-IV in renal collagen fibers was downregulated. To sum up, NSKP reduced the blood lipid of HFD mice, downregulated the inflammation of kidney, inhibited the expression of collagen fiber, and improved the renal fibrosis caused by long-term lipid metabolism disorder.