文献类型：期刊文献

英文题名：Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora

作者：Zhou, Yaxi[1];Wang, Diandian[1];Duan, Hao[1];Zhou, Shiqi[1];Guo, Jinhong[1];Guo, Yu[1];Zhao, Jian[1];Yan, Wenjie[1]

第一作者：Zhou, Yaxi

通讯作者：Yan, WJ[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2025

卷号：14

期号：2

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：;Scopus(收录号：2-s2.0-105000353857);WOS:【SCI-EXPANDED(收录号:WOS:001460987700002)】；

基金：This work was supported by the National Key Research and Development Program of China (2023YFF1103802) .

语种：英文

外文关键词：Silkworm pupa peptide; Ulcerative colitis; Intestinal barrier; Gut flora; Short-chain fatty acids

摘要：The anti-inflammatory properties of silkworm pupa peptide (SPP) have been recognized for their potential benefits in colitis treatment. However, the underlying mechanism of SPP in colitis animal models remains unclear. The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium (DSS)-induced colitis. The findings suggested that SPP effectively eased ulcerative colitis (UC) symptoms in mice by decreasing disease activity index, ameliorating histopathological injury, and decreasing serum and colonic markers of inflammation. In addition, our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1 (ZO-1), claudin-1, claudin-3, occludin, and adherens junction protein E-cadherin1. Further, SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut. These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis. (c) 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).