文献类型：期刊文献

英文题名：A fluorescent chemosensor for the sequential detection of copper(II) and histidine and its biological applications

作者：Wang, Dan[1];Zheng, Jian-Quan[2];Zheng, Xiang-Jun[1];Fang, De-Cai[1];Yuan, Da-Qiang[3];Jin, Liu-Pei[1]

第一作者：Wang, Dan

通讯作者：Zheng, XJ[1]

机构：[1]Beijing Normal Univ, Coll Chem, Beijing Key Lab Energy Convers & Storage Mat, Beijing 100875, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[3]Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China

第一机构：Beijing Normal Univ, Coll Chem, Beijing Key Lab Energy Convers & Storage Mat, Beijing 100875, Peoples R China

通讯机构：[1]corresponding author), Beijing Normal Univ, Coll Chem, Beijing Key Lab Energy Convers & Storage Mat, Beijing 100875, Peoples R China.

年份：2016

卷号：228

起止页码：387-394

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20160501866107);Scopus(收录号：2-s2.0-84955516177);WOS:【SCI-EXPANDED(收录号:WOS:000371027900050)】；

语种：英文

外文关键词：Fluorescence chemosensor; Copper; Histidine; Crystal structure; Cell imaging

摘要：A new fluorescent sensor 6-(2,3-dihydroxyphenyl)-5,6-dihydrobenzoimidazo[1,2-c] quinazoline (H2L) and the Zn(II) complex [Zn2L21]center dot C2H5OH (H2L1 = 3-{[2-(1H-benzoimidazol-2-yl)-phenylimino]-methyl}-benzene-1,2-diol) (1) were synthesized and characterized by single-crystal X-ray diffraction. H2L can be used to recognize Cue' in aqueous media as an on-off fluorescent sensor, forming the Cu(II) Schiff-base complex (CuLl). Furthermore, CuL1 can serve as an off-on fluorescent sensor to detect histidine (His) via the ligand displacement approach. The sequential detection of Cu(II) and histidine shows on-off-on phenomenon. The crystal structure of the dinuclear Zn(II) complex indicates that the coordination of H2L with Zn(II) promotes C N bond breakage, resulting in the quinazoline ring-opening of H2L to form the Zn(II) Schiff-base complex (1). The experimental results proved that H+ can also assist the ring-opening of H2L to form a Schiff base, H2L1.H2L is stable in neutral and weak basic solutions. This is further confirmed by the theoretical calculations. The cell imaging studies indicated that H2L and CuL1 can be used to detect the intracellular Cu2+ ion and His under physiological conditions, respectively. CuL1 can also be used to determine His in urine. 2016 Elsevier B.V. All rights reserved.