文献类型：期刊文献

英文题名：One-Dimensional Rod-like Tobacco Mosaic Virus Promotes Macrophage Polarization for a Tumor-Suppressive Microenvironment

作者：Ou, Jinzhao[1,2];Zhu, Meng[1];Ju, Xiaoyan[1];Xu, Dandan[1];Lu, Guojun[1];Li, Kejia[1];Jiang, Wei[1];Wan, Chenxiao[1];Zhao, Yuexia[3];Han, Yongping[3];Tian, Ye[1];Niu, Zhongwei[1,2,4]

第一作者：Ou, Jinzhao

通讯作者：Tian, Y[1];Niu, ZW[1];Niu, ZW[2];Niu, ZW[3]

机构：[1]Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China;[2]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[3]Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China;[4]Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

第一机构：Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China;[2]corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[3]corresponding author), Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China.

年份：0

外文期刊名：NANO LETTERS

收录：;EI(收录号：20230613537424);Scopus(收录号：2-s2.0-85147222337);WOS:【SCI-EXPANDED(收录号:WOS:000925329800001)】；

基金：This work was supported by the National Natural Science Foundation of China (31971303 and 52073293) , the Beijing Natural Science Foundation (7182110) , the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017039) , the Cross Training Plan for High Level Talents in Beijing and the Presidential Foundation of Technical Institute of Physics and Chemistry. We thank Dr. Xianlan Duan for the help with the qRT-PCR and Western blotting.

语种：英文

外文关键词：macrophage polarization; tobacco mosaic virus; tumor microenvironment; Toll-like receptor-4

摘要：The phenotype of tumor-associated macrophages plays an important role in their function of regulating the tumor immune microenvironment. The M1-phenotype macrophages display tumor-killing and immune activating functions. Here we show that the tobacco mosaic virus (TMV), a rod-like plant virus, can polarize macrophages to an M1 phenotype and shape a tumor-suppressive microenvironment. RAW 264.7 cells and bone marrow derived-macrophages (BMDMs) can recognize TMV via Toll-like receptor-4, and then the MAPK and NF-kappa B signaling pathways are activated, leading to the production of pro-inflammatory factors. Furthermore, the in vivo assessments on a subcutaneous co-injection tumor model show that the TMV-polarized BMDMs shape a tumor-suppressive microenvironment, resulting in remarkable delay of 4T1 tumor growth. Another in vivo assessment on an established tumor model indicates the high tumor-metastasis-inhibiting capacity of TMV-polarized BMDMs. This work suggests a role for this plant virus in macrophage-mediated therapeutic approaches and provides a strategy for tumor immunotherapy.