文献类型：期刊文献

英文题名：Effect of haematococcus pluvialis on exercise-related renal ischemia-reperfusion injury and ECM expression

作者：Wang, Juan[1];Cao, Jian-Min[2];Huang, An-Long[1];Zhou, Hai-Tao[3];Huo, Qin[3];Niu, Yan-Long[2]

第一作者：Wang, Juan

通讯作者：Zhou, HT[1]

机构：[1]Chu Zhou Univ, Phys Educ Coll, Chuzhou 239000, Anhui, Peoples R China;[2]Beijing Sport Univ, Sport Sci Coll, Beijing 100084, Peoples R China;[3]Beijing Union Univ, Biochem Engn Coll, 18,Zone 3, Beijing 100023, Peoples R China

第一机构：Chu Zhou Univ, Phys Educ Coll, Chuzhou 239000, Anhui, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Biochem Engn Coll, 18,Zone 3, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2016

卷号：9

期号：4

起止页码：7127-7136

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

收录：;Scopus(收录号：2-s2.0-84964873967);WOS:【SCI-EXPANDED(收录号:WOS:000377102200008)】；

基金：This work was financially supported by 2014 Beijing Natural Science Foundation-Beijing Institute of Science and Technology jointly funded projects L140006 and National Natural Science Foundation of China (Grant No. 114-75020).

语种：英文

外文关键词：Haematococcus pluvialis; exercise-related renal ischemia reperfusion injury; inflammatory factor; TGF-beta 1; extracellular matrix

摘要：This paper was to study the effect of haematococcus pluvialis on exercise-related renal ischemia reperfusion injury, rat renal tissue inflammatory factors and ECM expression. In the experiment, the rats were provided with 450 mg/kg haematococcus pluvialis intragastric administration for 56 d and were given with incremental load swimming training additionally. The glomerular ECM deposition and test serum urea nitrogen, creatinine, renal tissue inflammatory factor protein, gene expression, TGF-beta 1 gene expression and other biochemical indicators were observed after 24 h of the last exercise. The results showed that the rats suffered from exercise-related renal ischemia reperfusion, reinforcement of ECM deposition and renal function injury after 8 weeks' overtraining. Of glomerulus ECM deposition, it showed no significant difference (P > 0.05) among the quiet control group (Group C), general training group (Group M) and overtraining group (Group OM). Compared with Group C and Group M, overtraining group (Group OM) significantly increased (P < 0.01); haematococcus pluvialis+ overtraining group (Group HM) was significantly lower than that in Group OM (P < 0.05). (2) With respect to serum urea nitrogen and creatinine level, OM group and HM group were significantly higher than those of Group C (P < 0.01) and HM group was significantly lower than that in the OM group (P < 0.05); as for renal tissue TNF alpha, IL-1 beta, IL-6 and IL-18 protein expression, the OM group and HM group were significantly higher than those of Group C (P < 0.01) and HM group was significantly lower than that in the OM group (P < 0.05); as for renal tissue TNF-alpha mRNA and IL-1 beta mRNA and IL-6 mRNA and IL-18 mRNA expression, OM group and HM group were significantly higher than those of group C (P < 0.01) and HM group was significantly lower than that in the OM group (P < 0.05); as far as renal tissue TGF-beta 1 mRNA expression was concerned, HM group (P < 0.05) and OM group (P < 0.01) were significantly higher than those of C group and HM group was significantly lower than that in the OM group (P < 0.05). It is demonstrated that Haematococcus pluvialis can effectively inhibit inflammatory factor expression in the renal tissue so as to reduce kidney tissue TGF-beta 1 expression in case of exercise-related renal ischemia reperfusion induced by the overtraining, maintain ECM homeostasis and delay or avoid the damage to the kidney.