文献类型：期刊文献

英文题名：Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

作者：Lin Peng-Cheng[1];Ji Lin-Lin[2];Zhong Xiang-Jian[2];Li Jin-Jie[2];Wang Xin[2];Shang Xiao-Ya[2];Lin Sheng[3,4]

第一作者：Lin Peng-Cheng

通讯作者：Shang, XY[1];Lin, S[2];Lin, S[3]

机构：[1]Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China;[2]Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[3]Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China;[4]Peking Union Med Coll, Beijing 100050, Peoples R China

第一机构：Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China;[3]corresponding author), Peking Union Med Coll, Beijing 100050, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2019

卷号：17

期号：1

起止页码：22-26

外文期刊名：CHINESE JOURNAL OF NATURAL MEDICINES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000456809300004)】；

基金：This work were supported by the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); the National Natural Science Foundation of China (Nos. 81522050, 81773589 and 81760783); the Science and Technology program of Qinghai (No. 2018-ZJ-739), and the Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201811417008).

语种：英文

外文关键词：Cirsium setosum; Taraxastane-type triterpenoid; TNF-alpha secretion inhibitory activity; Cytotoxicity

摘要：Guided by TNF-alpha secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3 beta, 30-diol (1) and 22 alpha-hydroxy-20-taraxasten-30 beta, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-alpha secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 mu mol.L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.