文献类型：期刊文献

英文题名：Identification of Elaiophylin Derivatives from the Marine-Derived Actinomycete Streptomyces sp 7-145 Using PCR-Based Screening

作者：Wu, Chunyan[1,2,3,4];Tan, Yi[1,2];Gan, Maoluo[1,2,3];Wang, Yiguang[1,2];Guan, Yan[1,2];Hu, Xinxin[1,2];Zhou, Hongxia[1,2];Shang, Xiaoya[4];You, Xuefu[1,2];Yang, Zhaoyong[1,2];Xiao, Chunling[1,2]

第一作者：Wu, Chunyan

通讯作者：Gan, ML[1]

机构：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China;[2]Peking Union Med Coll, Beijing 100050, Peoples R China;[3]Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China;[4]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China.

年份：2013

卷号：76

期号：11

起止页码：2153-2157

外文期刊名：JOURNAL OF NATURAL PRODUCTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327677800024)】；

基金：Financial support from the Natural Sciences Foundation of China (NSFC, Grant Nos. 81273414 and 81001386), the Beijing Natural Science Foundation (No. 5122032), and the National Science and Technology Project of China (Grant Nos. 2014ZX09507009-008 and 2012ZX09301002-003) is gratefully acknowledged.

语种：英文

摘要：A PCR-based genetic screening experiment targeting the dTDP-glucose-4,6-dehydratase gene revealed that a marine sediment-derived strain, Streptomyces sp. 7-145, had the potential to produce glycosidic antibiotics. Chemical investigation of culture extracts of this strain yielded two new 6-deoxyhexose-containing antibiotics, 11',12'-dehydroelaiophylin (1) and 11,11'-O-dimethyl-14'-deethyl-14'-methylelaiophylin (2), together with four known elaiophylin analogues (3-6). Their structures were determined by extensive NMR, MS, and CD analyses. Compounds 1, 3, 4, and 6 showed good antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci pathogens.