文献类型：期刊文献

英文题名：Study of the self-assembly, drug encapsulating and delivering characteristics of short chain amylose-based type 3 resistant starch nanoparticles from Canna edulis

作者：Zhang, Chi[3];Tang, Leimengyuan[1];Wang, Nan[1];Wu, Jiahui[1];Zhang, Dachuan[1];Li, Houxier[1];Li, Yan[1];Yang, Li[1];Zhang, Nan[1];Zhang, Yuan[2];Wang, Xueyong[1]

第一作者：Zhang, Chi

通讯作者：Wang, XY[1];Zhang, Y[2]

机构：[1]Beijing Univ Chinese Med, Sch Chinese Meteria Med, Northeast corner Intersect Sunshine South St & Bai, Beijing 102488, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, 18 Fatou Xili Dist, Beijing 100023, Peoples R China;[3]Linyi Univ, Sch Med, Linyi 276000, Shandong, Peoples R China

第一机构：Beijing Univ Chinese Med, Sch Chinese Meteria Med, Northeast corner Intersect Sunshine South St & Bai, Beijing 102488, Peoples R China

通讯机构：[1]corresponding author), Beijing Univ Chinese Med, Sch Chinese Meteria Med, Northeast corner Intersect Sunshine South St & Bai, Beijing 102488, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Biochem Engn, 18 Fatou Xili Dist, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2024

卷号：262

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001199034800001)】；

基金：This work was supported by grants from the Science and Technology support project in Guizhou Province ( [2020] 4Y074) .

语种：英文

外文关键词：Resistant starch nanoparticles; Short chain amylose; Self -assembly; colon target delivering system; Drug delivery

摘要：In developing type 3 resistant starch (RS3) from Canna edulis for use as functional food ingredients, we investigated the synthesis of C. edulis RS3 nanoparticles. Simultaneously, we explored the potential of C. edulis short-chain amylose (SCA)-based RS3 nanoparticles (RS3N) as a targeted delivery system, with a specific focus on colon targeting, yielding promising insights. Our study revealed that the degree of polymerization (DP) of C. edulis SCA, particularly the chains of DP 36- 100, exhibited a robust correlation with the particle size and physicochemical characteristics of C. edulis SCA-based RS3N. Additionally, recrystallization temperature variation (4, 25, and 45 degrees C) significantly influenced the self-assembly behavior of C. edulis SCA, with the preparation at 4 degrees C resulting in more uniform particle size distributions. In further expanding the scope of applications for C. edulis SCA-based RS3N, we harnessed the potential of Fe3O4 and curcumin (CUR) as guest molecules to assess drug encapsulation and colon-targeting capabilities. Incorporating Fe3O4 into the self-assembly system led to the production of magnetic RS3N, confirming the successful encapsulation of Fe3O4 within C. edulis SCA-based RS3N. Furthermore, in vitro experiments have demonstrated that CUR-RS3N was stable in the gastrointestinal tract and gradually released curcumin with fermentation in the colonic environment. Collectively, these findings provide invaluable insights into the intricate self-assembly behavior of C. edulis SCA with varying fine structures and recrystallization temperatures during RS3N formation. Moreover, they underscore the colon-targeted properties of C. edulis SCA-based RS3N, opening promising avenues for its application within the food industry, particularly in advanced controlled drug delivery systems.