文献类型：期刊文献

英文题名：Targeting HDACs: A Promising Therapy for Alzheimer's Disease

作者：Xu, Ke[2];Dai, Xue-Ling[1,3];Huang, Han-Chang[1];Jiang, Zhao-Feng[1,4]

第一作者：Xu, Ke

通讯作者：Jiang, ZF[1]

机构：[1]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China;[2]Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China;[3]Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China;[4]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;

年份：2011

卷号：2011

外文期刊名：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

收录：;EI(收录号：20114714549127);Scopus(收录号：2-s2.0-81555207184);WOS:【SCI-EXPANDED(收录号:WOS:000296867200001)】；

基金：This research was supported by Project 31071512 supported by the National Natural Science Foundation of China and by the Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality (PHR(IHLB)) (PHR20090514).

语种：英文

外文关键词：Acetylation - Alkylation - Disease control - Proteins

摘要：Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.