文献类型：期刊文献

英文题名：New Cytotoxic Azaphilones from Monascus purpureus-Fermented Rice (Red Yeast Rice)

作者：Li, Jin-Jie[1];Shang, Xiao-Ya[1];Li, Ling-Ling[1];Liu, Ming-Tao[2,3];Zheng, Jian-Quan[1];Jin, Zong-Lian[1]

第一作者：李金杰

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100083, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100083, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2010

卷号：15

期号：3

起止页码：1958-1966

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000275956900060)】；

基金：We gratefully acknowledge financial support from the Beijing Natural Sciences Foundation (Grant No. 7102020); Beijing Education Commission (Grant No. KM200811417009) and Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University (Grant No. LDKZ-0605).

语种：英文

外文关键词：Monascus purpureus; cytotoxicity; azaphilones; absolute configurations

摘要：Using a cell-based cytotoxicity assay three new cytotoxic azaphilones, including two stereoisomers and designated monapurones A-C (1-3), were isolated from the extract of Monascus purpureus-fermented rice (red yeast rice). Their structures were elucidated by detailed interpretation of spectroscopic and chemical data. The relative configurations were assigned on the basis of analysis of NOE data, and the absolute configurations were determined by direct comparison of their CD spectra with those of known azaphilones and chemical correlations. In the in vitro assays, monapurones A-C (1-3) showed selective cytotoxicity against human cancer cell line A549 with IC50 values of 3.8, 2.8 and 2.4 mu M respectively, while exhibiting no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.