文献类型：期刊文献

英文题名：Chemical characterization of the anti-inflammatory activity fraction of Epilobium angustifolium

作者：Lin, Pengcheng[1]; Wang, Xin[2]; Zhou, Na[2]; Wu, Yong[2]; Wang, Zeyu[2]; Wu, Lei[1]; Li, Jinjie[2]; Shang, Xiaoya[2]

第一作者：Lin, Pengcheng

通讯作者：Shang, Xiaoya

机构：[1] Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China; [2] Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, China

第一机构：Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining, 810000, China

通讯机构：[2]Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, China|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2022

卷号：248

期号：1

起止页码：35-44

外文期刊名：European Food Research and Technology

收录：EI(收录号：20214111008907);Scopus(收录号：2-s2.0-85116802910)

语种：英文

外文关键词：Antennas - Ethanol

摘要：The air-dried aerial part of Epilobium angustifolium is a very popular recreational tea in the Eastern edge of Europe. Studies have found that the extract of E. angustifolium has strong anti-inflammatory effects, and the oenothein B contained therein is speculated the main anti-inflammatory component. In this study, a fraction without oenothein B from the ethanol extract of E. angustifolium exhibited a much stronger anti-inflammatory activity than that of the oenothein B. Guided by rapid characterization of the chemical compositions based on UPLC–Orbitrap–MS/MS, a total of 39 compounds, including 20 flavonoids and 19 other phenolic acids were identified in the active fraction, based on the accurate mass within 3?ppm error. Further investigation resulted in the isolation and identification of 10 compounds, one of which was a new compound, and four known compounds were identified in E. angustifolium for the first time. All isolated compounds exhibited significant inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 cells. This study indicated that the anti-inflammatory active ingredients in E. angustifolium were mainly concentrated in the 30% ethanol eluted fraction obtained over macroporous adsorption resin. In addition to the oenothein B, there are a large number of other more effective anti-inflammatory components in E. angustifolium. ? 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.