文献类型：期刊文献

英文题名：New polymerized sesquiterpene lactones from Ainsliaea yunnanensis and their activity evaluation

作者：Zhou, Na[1];Li, Jin-Jie[1];Wu, Yong[1];Wang, Ze-Yu[1];Wang, Xin[1];Yin, Zhi-Peng[1];Wang, Xin-Peng[1];Liu, Yi-Ran[1];Shang, Xiao-Ya[1]

第一作者：Zhou, Na

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2022

卷号：36

期号：19

起止页码：4862-4868

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000637571700001)】；

基金：This work was supported by the [Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee] under Grant [number KZ201811417049]; [R&D Program of Beijing Municipal Education Commission] under Grant [number KM202011417014]; [Premium Funding Project for Academic Human Resources Development in Beijing Union University] under Grant [number BPHR2019DZ03]; and [Beijing Union University Graduate Research and Innovation Fund Project] under Grant [number YZ2020K001].

语种：英文

外文关键词：Ainsliaea yunnanensis; sesquiterpene lactones; structures; activity evaluation

摘要：Two new dimeric and trimeric sesquiterpene lactones (1-2), and nine known sesquiterpene lactones (3-11) were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were identified by NMR, IR and HR-ESIMS spectroscopic methods, and compound 1 was confirmed by single crystal X-ray diffraction experiment. All the compounds were tested for their cytotoxic, anti-microbial and anti-inflammatory activities. Compounds 1, 2, 3, 5, 7, 9 and 11 showed very significant selective cytotoxic activities on MDA-MB-468, PANC-1, HEPG2 or A549 cells. Compounds 6 and 11 showed very significant inhibiting effect on Epicoccum sp. (CPCC 400307), Fusarium solani (CPCC 800013) or Bacillus subtilis. Meanwhile, compounds 6 and 7 can inhibit the NLRP3 inflammasome's activation at the concentration of 10 mu M.