文献类型：期刊文献

英文题名：Study on the angiogenesis ability of Polymethyl methacrylate-mineralized collagen/Mg-Ca composite material in vitro and the bone formation effect in vivo

作者：Bao, Jiaxin[1];Sun, Xirao[1];Chen, Zhan[1];Yang, Jingxin[2,3];Wang, Chengyue[1]

第一作者：Bao, Jiaxin

通讯作者：Wang, CY[1]

机构：[1]Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Informat Serv Engn, Beijing, Peoples R China;[3]Beijing Union Univ, Coll Robot, Beijing, Peoples R China

第一机构：Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China

通讯机构：[1]corresponding author), Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China.

年份：0

外文期刊名：JOURNAL OF BIOMATERIALS APPLICATIONS

收录：;EI(收录号：20223412600122);Scopus(收录号：2-s2.0-85136034312);WOS:【SCI-EXPANDED(收录号:WOS:000840495800001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Key research project of Liaoning Provincial Department of Education (grant number JYTZD2020004), the Academic Research Projects of Beijing Union University (grant number ZK70202006), Liaoning Provincial Natural Fund Subsidy Program (grant number 2019-MS-141).

语种：英文

外文关键词：mineralized collagen; Mg-Ca alloy; osteogensis; angiogenesis

摘要：Magnesium (Mg) and its alloys show high degrees of biocompatibility and biodegradability, used as biodegrad able materials in biomedical applications. In this study, Polymethyl methacrylate (PMMA) - mineralized collagen (nano-Hydroxyapatite/collagen; nHAC)/Mg-Ca composite materials were prepared, to study the angiogenesis ability of its composite materials on Human umbilical vein endothelial cells (HUVECs) and its osteogenesis effect in vivo. The results showed that the PMMA-nHAC reinforcement materials can promote the proliferation and adhesion in HUVECs of Mg matrix significantly, it can enhance the migration motility and VEGF expression of HUVECs. In vivo, Micro-CT examination showed that with coated samples presenting the highest bone formation. Histologically, the materials and their corrosion products caused no systematic or local cytotoxicological effects. Therefore, the Mg matrix composites prepared in the present study has good biocompatibility and PMMA-nHAC/Mg-Ca composite may be an ideal orthopedic material to improve the bone formation, and biodegradable magnesium based implants with bioactivity have potential applications in bone tissue.