文献类型：期刊文献

英文题名：Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum

作者：Liu, Sushi[1,2];Fan, Wenwen[2];Ren, Jinwei[2];Wang, Wenzhao[2];Liu, Xingzhong[2];Liang, Yonghong[3];Wei, Tao[1];Li, Erwei[2]

第一作者：Liu, Sushi

通讯作者：Wei, T[1];Li, EW[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China;[3]Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2021

卷号：148

外文期刊名：FITOTERAPIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000604579800014)】；

基金：This work was supported by National Special Project for Key Science and Technology of Food Safety (No. 2017YFC1601300), and the Research Project Supported by Beijing Union University Graduate Student Scientific Research Innovation (YZ2020K001). We also thank Dr. P. Fu (School of Medicine and Pharmacy, Ocean University of China) for Gaussian and computing access.

语种：英文

外文关键词：Penicillium janthinellum; Entomogenous fungus; Sesquiterpenoid; Antibacterial activity

摘要：Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. The absolute configuration of the C-8 secondary alcohol of peniterpenoid B (2) was determined by [Rh-2(OCOCF3)(4)]-induced ECD experiment. Subsequently, the antimicrobial and DPPH scavenging activities were determined. Compounds 6 8 exhibited moderate antibacterial activities against Staphylococcus aureus (CGMCC1.2465) with MIC values of 25.0, 50.0 and 12.5 mu g/mL, respectively.