文献类型：期刊文献

英文题名：Taurine supplementation decreases fat accumulation by suppressing FAS and enhancing ATGL through the ATGL pathway

作者：Geng, Xueying[1];Feng, Yafang[1];Yu, Congcong[1];Yao, Yuyang[1];Chen, Wen[1,2];Guo, Junxia[1,2];Zhang, Yanzhen[1,2];Zhang, Jing[1,2];Mi, Shengquan[1,2]

第一作者：Geng, Xueying

通讯作者：Mi, SQ[1];Mi, SQ[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2024

卷号：27

期号：12

起止页码：1529-1535

外文期刊名：IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES

收录：;Scopus(收录号：2-s2.0-85206941095);WOS:【SCI-EXPANDED(收录号:WOS:001339791200005)】；

基金：The results presented in this paper were part of a student thesis. This research was funded by the "Premium Funding Project for Academic Human Resources Development in Beijing Union University (BPHR2017CZ03)" (Beijing, China) .

语种：英文

外文关键词：Animal models; Atglistatin; High-fat diet; Lipid metabolism; Enzymes; Taurine

摘要：Objective(s): Obesity leads to severe health issues like cardiovascular disease. Natural substances with anti-obesity properties are gaining attention. This study investigates the impact of taurine on lipid levels in rats fed a high-fat diet. Materials and Methods: The SD rats were fed a high-fat diet and treated with or without taurine for 21 weeks. Taurine was added to their drinking water, and an adipose triglyceride lipase (ATGL) inhibitor was injected for one week. The study evaluated the impact of taurine supplementation on the rats' body weight, Lee index, body fat content, serum levels of triglycerides (TG), total cholesterol acid synthase (FAS), ATGL, and peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver. Fat accumulation in the liver and aortic arch was assessed through histopathological observations. Results: The study found that taurine reduced body weight, body fat, serum TG, TC, LDL-C levels, and lipid deposition in the liver and aortic arch while increasing serum HDL-C levels. Taurine intake also increased FAS and ATGL expression in the liver. Interestingly, the ATGL inhibitor atglistatin did not affect FAS and ATGL expression in the presence of taurine. Conclusion: Taurine can reduce fat deposition caused by a high-fat diet in SD rats by decreasing FAS content and increasing ATGL content. However, taurine does not fully regulate FAS and ATGL expression through the ATGL pathway.